RT Journal Article
T1 Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling.
A1 Gómez-Oliva, Ricardo
A1 Geribaldi-Doldán, Noelia
A1 Domínguez-García, Samuel
A1 Carrascal, Livia
A1 Verástegui, Cristina
A1 Nunez-Abades, Pedro
A1 Castro, Carmen
K1 Wnt signaling
K1 cognitive performance
K1 neural stem cells
K1 neurogenesis
K1 vitamin D
AB Vitamin D is an essential fat-soluble vitamin that participates in several homeostatic functions in mammalian organisms. Lower levels of vitamin D are produced in the older population, vitamin D deficiency being an accelerating factor for the progression of the aging process. In this review, we focus on the effect that vitamin D exerts in the aged brain paying special attention to the neurogenic process. Neurogenesis occurs in the adult brain in neurogenic regions, such as the dentate gyrus of the hippocampus (DG). This region generates new neurons that participate in cognitive tasks. The neurogenic rate in the DG is reduced in the aged brain because of a reduction in the number of neural stem cells (NSC). Homeostatic mechanisms controlled by the Wnt signaling pathway protect this pool of NSC from being depleted. We discuss in here the crosstalk between Wnt signaling and vitamin D, and hypothesize that hypovitaminosis might cause failure in the control of the neurogenic homeostatic mechanisms in the old brain leading to cognitive impairment. Understanding the relationship between vitamin D, neurogenesis and cognitive performance in the aged brain may facilitate prevention of cognitive decline and it can open a door into new therapeutic fields by perspectives in the elderly.
YR 2020
FD 2020-06-17
LK http://hdl.handle.net/10668/15763
UL http://hdl.handle.net/10668/15763
LA en
DS RISalud
RD Apr 11, 2025