RT Journal Article
T1 Pegylated Interferon-α-Induced Natural Killer Cell Activation Is Associated With Human Immunodeficiency Virus-1 DNA Decline in Antiretroviral Therapy-Treated HIV-1/Hepatitis C Virus-Coinfected Patients.
A1 Hua, Stéphane
A1 Vigano, Selena
A1 Tse, Samantha
A1 Zhengyu, Ouyang
A1 Harrington, Sean
A1 Negron, Jordi
A1 Garcia-Broncano, Pilar
A1 Marchetti, Giulia
A1 Genebat, Miguel
A1 Leal, Manuel
A1 Resino, Salvador
A1 Ruiz-Mateos, Ezequiel
A1 Lichterfeld, Mathias
A1 Yu, Xu G
AB Interferon alpha (IFN-α) can potently reduce human immunodeficiency virus type 1 (HIV-1) replication in tissue culture and animal models, but may also modulate residual viral reservoirs that persist despite suppressive antiretroviral combination therapy. However, mechanisms leading to viral reservoir reduction during IFN-α treatment are unclear. We analyzed HIV-1 gag DNA levels in CD4 T cells by digital droplet polymerase chain reaction and CD8 T-cell and natural killer (NK) cell phenotypes by flow cytometry in a cohort of antiretroviral therapy-treated HIV-1/hepatitis C virus-coinfected patients (n = 67) undergoing treatment for hepatitis C infection with pegylated IFN-α and ribavirin for an average of 11 months. We observed that IFN-α treatment induced a significant decrease in CD4 T-cell counts (P  These data suggest that the reduction of viral reservoir cells during treatment with IFN-α is primarily attributable to antiviral activities of NK cells.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/11943
UL http://hdl.handle.net/10668/11943
LA en
DS RISalud
RD Apr 12, 2025