RT Journal Article
T1 Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227.
A1 Braña, Alfredo F
A1 Sarmiento-Vizcaíno, Aida
A1 Pérez-Victoria, Ignacio
A1 Otero, Luis
A1 Fernández, Jonathan
A1 Palacios, Juan José
A1 Martín, Jesús
A1 de la Cruz, Mercedes
A1 Díaz, Caridad
A1 Vicente, Francisca
A1 Reyes, Fernando
A1 García, Luis A
A1 Blanco, Gloria
AB Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated from deep seawater of the Avilés submarine Canyon. Their structures were elucidated by HRMS and NMR analyses. These compounds exhibit antibacterial activities against a panel of Gram-positive bacteria, including Corynebacterium urealyticum, Clostridium perfringens, and Micrococcus luteus, and against the Gram-negative bacterium Neisseria meningitidis. Additionally, branimycin B displayed moderate antibacterial activity against other Gram-negative bacteria such as Bacteroides fragilis, Haemophilus influenzae, and Escherichia coli, and branimycin C against the Gram-positive Enterococcus faecalis and methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
YR 2017
FD 2017-02-07
LK http://hdl.handle.net/10668/10849
UL http://hdl.handle.net/10668/10849
LA en
DS RISalud
RD Aug 31, 2025