%0 Journal Article
%A Braña, Alfredo F
%A Sarmiento-Vizcaíno, Aida
%A Pérez-Victoria, Ignacio
%A Otero, Luis
%A Fernández, Jonathan
%A Palacios, Juan José
%A Martín, Jesús
%A de la Cruz, Mercedes
%A Díaz, Caridad
%A Vicente, Francisca
%A Reyes, Fernando
%A García, Luis A
%A Blanco, Gloria
%T Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227.
%D 2017
%U http://hdl.handle.net/10668/10849
%X Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated from deep seawater of the Avilés submarine Canyon. Their structures were elucidated by HRMS and NMR analyses. These compounds exhibit antibacterial activities against a panel of Gram-positive bacteria, including Corynebacterium urealyticum, Clostridium perfringens, and Micrococcus luteus, and against the Gram-negative bacterium Neisseria meningitidis. Additionally, branimycin B displayed moderate antibacterial activity against other Gram-negative bacteria such as Bacteroides fragilis, Haemophilus influenzae, and Escherichia coli, and branimycin C against the Gram-positive Enterococcus faecalis and methicillin-sensitive and methicillin-resistant Staphylococcus aureus.
%~