TY - JOUR AU - Muñoz-Castro, Clara AU - Noori, Ayush AU - Magdamo, Colin G AU - Li, Zhaozhi AU - Marks, Jordan D AU - Frosch, Matthew P AU - Das, Sudeshna AU - Hyman, Bradley T AU - Serrano-Pozo, Alberto PY - 2022 DO - 10.1186/s12974-022-02383-4 UR - http://hdl.handle.net/10668/20331 T2 - Journal of neuroinflammation AB - Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer's disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of these glial cells but lack... LA - en KW - Alzheimer’s disease KW - Amyloid plaques KW - Astrocytes KW - Immunohistochemistry KW - Microglia KW - Neurofibrillary tangles KW - Neuropathology KW - Tau KW - Alzheimer Disease KW - Astrocytes KW - Humans KW - Immunohistochemistry KW - Machine Learning KW - Microglia KW - Receptors, GABA TI - Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease. TY - research article VL - 19 ER -