RT Journal Article
T1 Effectiveness and Safety of Inhaled Antibiotics in Patients With Chronic Obstructive Pulmonary Disease. A Multicentre Observational Study.
A1 De la Rosa Carrillo, David
A1 Martínez-García, Miguel Ángel
A1 Barreiro, Esther
A1 Tabernero Huguet, Eva
A1 Costa Sola, Roser
A1 García-Clemente, Marta María
A1 Celorrio Jiménez, Nuria
A1 Rodríguez Pons, Laura
A1 Calero Acuña, Carmen
A1 Rodríguez Hermosa, Juan Luís
A1 Golpe, Rafael
A1 Dacal Quintas, Raquel
A1 Sánchez-Cuéllar, Silvia
A1 Torres Arroyo, Irene
A1 Blanco Aparicio, Marina
A1 Almadana Pacheco, Virginia
A1 Miravitlles, Marc
A1 Study group on the effectiveness of inhaled antibiotic treatment in COPD, 
A1 Study group on the effectiveness of inhaled antibiotic treatment in COPD, 
K1 Antibióticos inhalados
K1 Bronchiectasis
K1 Bronquiectasia
K1 Chronic bronchial infection
K1 Chronic obstructive pulmonary disease
K1 Enfermedad pulmonar obstructiva crónica
K1 Exacerbaciones
K1 Exacerbations
K1 Infección bronquial crónica
K1 Inhaled antibiotics
K1 Pseudomonas aeruginosa
AB We aimed to describe the effectiveness and safety of inhaled antibiotics in chronic obstructive pulmonary disease (COPD) patients, as well as the patient profile in which they are usually prescribed and the patient groups that can most benefit from this treatment. Multicentre retrospective observational cohort study in COPD patients who had received ≥1 dose of inhaled antibiotics in the last 5 years. Clinical data from the two years prior to and subsequent to the start of the treatment were compared. COPD exacerbations. side effects, symptomatology (sputum purulence, dyspnoea), microbiological profile and pathogen eradication. Of 693 COPD patients analyzed (aged 74.1; 86.3% men; mean FEV1=43.7%), 71.7% had bronchiectasis and 46.6% presented chronic bronchial infection (CBI) by Pseudomonas aeruginosa (PA). After 1 year of treatment with inhaled antibiotics, there was a significant decrease in the number of exacerbations (-33.3%; P In COPD patients with multiple exacerbations and/or CBI by any PPM (especially PA), inhaled antibiotics appear to be an effective and safe treatment, regardless of the presence of bronchiectasis.
YR 2021
FD 2021-03-19
LK http://hdl.handle.net/10668/21983
UL http://hdl.handle.net/10668/21983
LA en
LA es
DS RISalud
RD Apr 5, 2025