RT Journal Article
T1 Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression.
A1 Gomez-Fernandez, Antonio
A1 de la Torre-Aguilar, Maria J
A1 Gil-Campos, Mercedes
A1 Flores-Rojas, Katherine
A1 Cruz-Rico, Maria D
A1 Martin-Borreguero, Pilar
A1 Perez-Navero, Juan Luis
K1 Autism spectrum disorder
K1 Cell adhesion molecules
K1 Children
K1 Cytokines
K1 Neurodevelopmental regression
AB Background: In the etiopathogenesis of autism spectrum disorder (ASD), it has been suggested that a proinflammatory condition, as well as an alteration in adhesion molecules in the early stages of neurodevelopment, may play a role in the pathophysiology of the disorder. This study set out to evaluate the plasma levels of certain inflammatory cytokines, adhesion molecules, and growth factors in a sample of pediatric patients with ASD and compare them to the levels in a control group of healthy children. Methods: Fifty-four children (45 males and nine females) aged 2-6, who were diagnosed with ASD, and a control group of 54 typically-developing children of similar ages were selected. The diagnosis of ASD was carried out in accordance with the DSM-5 criteria and the data obtained from a developmental semi-structured clinical interview and the ADOS evaluation test. Additional testing was carried out to identify the children's developmental level and severity of ASD symptomatology. Patients with ASD were further divided into two subgroups based on developmental parameters: ASD children with neurodevelopmental regression (AMR) and ASD children without neurodevelopmental regression (ANMR). Analyses of plasma molecules, such as cathepsin, IL1β, IL6, IL8, MPO, RANTES, MCP, BDNF, PAI NCAM, sICAM, sVCAM and NGF, were performed. Results: Higher levels of NGF were observed in the ASD group compared with the levels in the control group (p< 0.05). However, in the analysis of the ASD subgroups,  lower plasma levels of NCAM and higher levels of NGF were found in the group of ASD children without evelopmental regression compared to the levels in the group of typically-developing children.
PB Frontiers Research Foundation
SN 2296-2360
YR 2018
FD 2018-09-05
LK http://hdl.handle.net/10668/13081
UL http://hdl.handle.net/10668/13081
LA en
NO Gomez-Fernandez A, de la Torre-Aguilar MJ, Gil-Campos M, Flores-Rojas K, Cruz-Rico MD, Martin-Borreguero P, et al. Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression. Front Pediatr. 2018 Sep 26;6:264
DS RISalud
RD Apr 10, 2025