RT Journal Article
T1 Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial.
A1 Buil-Cosiales, Pilar
A1 Toledo, Estefania
A1 Salas-Salvadó, Jordi
A1 Zazpe, Itziar
A1 Farràs, Marta
A1 Basterra-Gortari, Francisco Javier
A1 Diez-Espino, Javier
A1 Estruch, Ramon
A1 Corella, Dolores
A1 Ros, Emilio
A1 Marti, Amelia
A1 Gómez-Gracia, Enrique
A1 Ortega-Calvo, Manuel
A1 Arós, Fernando
A1 Moñino, Manuel
A1 Serra-Majem, Lluis
A1 Pintó, Xavier
A1 Lamuela-Raventós, Rosa Maria
A1 Babio, Nancy
A1 Gonzalez, Jose I
A1 Fitó, Montserrat
A1 Martínez-González, Miguel A
A1 PREDIMED investigators, 
K1 CVD
K1 DF dietary fibre
K1 Dietary fibre
K1 FC fruit consumption
K1 Fruits
K1 HR hazard ratios
K1 MI myocardial infarction
K1 PREDIMED PREvención con DIeta MEDiterránea
K1 Primary prevention
K1 T2D type 2 diabetes
K1 Vegetables
AB Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated measurements of dietary changes during follow-up. Moreover, previous studies included healthy and selected participants who did not represent subjects at high cardiovascular risk. We used yearly repeated measurements of diet to investigate the association between fibre intake and CVD in a Mediterranean cohort of elderly adults at high cardiovascular risk. We followed-up 7216 men (55-80 years) and women (60-80 years) initially free of CVD for up to 7 years in the PREvención con DIeta MEDiterránea study (registered as ISRCTN35739639). A 137-item validated FFQ was repeated yearly to assess diet. The primary end point, confirmed by a blinded ad hoc Event Adjudication Committee, was a composite of cardiovascular death, myocardial infarction and stroke. Time-dependent Cox's regression models were used to estimate the risk of CVD according to baseline dietary exposures and to their yearly updated changes. We found a significant inverse association for fibre (P for trend=0·020) and fruits (P for trend=0·024) in age-sex adjusted models, but the statistical significance was lost in fully adjusted models. However, we found a significant inverse association with CVD incidence for the sum of fruit and vegetable consumption. Participants who consumed in total nine or more servings/d of fruits plus vegetables had a hazard ratio 0·60 (95 % CI 0·40, 0·96) of CVD in comparison with those consuming
YR 2016
FD 2016-06-06
LK http://hdl.handle.net/10668/10153
UL http://hdl.handle.net/10668/10153
LA en
DS RISalud
RD Apr 7, 2025