RT Generic
T1 Vitamin D Intake and the Risk of Colorectal Cancer: An Updated Meta-Analysis and Systematic Review of Case-Control and Prospective Cohort Studies.
A1 Boughanem, Hatim
A1 Canudas, Silvia
A1 Hernandez-Alonso, Pablo
A1 Becerra-Tomás, Nerea
A1 Babio, Nancy
A1 Salas-Salvadó, Jordi
A1 Macias-Gonzalez, Manuel
K1 case-control
K1 colorectal cancer
K1 incidence
K1 meta-analysis
K1 prospective
K1 systematic review
K1 vitamin D intake
AB Obesity, a sedentary lifestyle, high red meat consumption and alcohol, and tobacco are considered the driving factors behind colorectal cancer (CRC) worldwide. Both diet and lifestyle are recognized to play an important role in the prevention of CRC. Forty years later, the vitamin D-cancer hypothesis is considered consistent. However, the relationship between low vitamin D intake and CRC is still controversial. The aim of this meta-analysis is to determine the associations between Vitamin D intake and CRC. MEDLINE-PubMed and Cochrane databases were searched up to May 2020 for studies evaluating the association between vitamin D intake (from foods and supplements) and CRC. Two reviewers, working independently, screened all titles and abstracts to identify the studies that met the inclusion criteria (case-control or prospective cohort (PC) studies published in English). Data were pooled by the generic inverse variance method using a random or fixed effect model. Heterogeneity was identified using the Cochran Q-test and quantified by the I2 statistic. A total of 31 original studies were included for the quantitative meta-analysis, comprising a total 47.540 cases and 70.567 controls in case-control studies, and a total of 14.676 CRC-incident cases (out of 808.130 subjects in PC studies) from 17 countries. A significant 25% lower risk was reported comparing the highest vs. the lowest dietary vitamin D consumption and CRC risk (odds ratio (95% confidence interval): 0.75 (0.67; 0.85)) in case-control studies, whereas a non-significant association was reported in case of prospective studies (hazard ratio (95% confidence interval): 0.94 (0.79; 1.11). The present meta-analysis demonstrates that high dietary vitamin D is associated to CRC prevention. However, larger and high-quality prospective studies and clinical trials are warranted to confirm this association.
PB Mdpi
SN 2072-6694
YR 2021
FD 2021-06-04
LK http://hdl.handle.net/10668/18079
UL http://hdl.handle.net/10668/18079
LA en
NO Boughanem H, Canudas S, Hernandez-Alonso P, Becerra-Tomás N, Babio N, Salas-Salvadó J, et al. Vitamin D Intake and the Risk of Colorectal Cancer: An Updated Meta-Analysis and Systematic Review of Case-Control and Prospective Cohort Studies. Cancers (Basel). 2021;13(11):2814. Published 2021 Jun 4.
NO This study is supported by Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain, which is financed by the European Regional Development Fund (ERDF), “A way to make Europe”/”Investing in your future” (CB06/03) and a grant from ISCIII (PI18/01399). P.H.-A. and N.B.-T. are supported by a postdoctoral fellowship (Juan de la Cierva-Formación), FJCI-2017-32205 and FJC2018-036016-I, respectively funded by the Ministerio de Ciencia, Innovación y Universidades. A grant from ISCIII (PI18/01399). HB is supported by a predoctoral fellowship (“Plan Propio IBIMA 2020 A.1 Contratos predoctorales”, Ref.: predoc20_002). MMG. was the recipient of the Nicolas Monardes Program from the “Servicio Andaluz de Salud, Junta de Andalucía”, Spain (RC-0001-2018 and C-0029-2014). This study was funded by the National Institutes of Health, the Spanish Ministry of Health and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional. This work is partially supported by ICREA under the ICREA Academia programme.
DS RISalud
RD Oct 25, 2025