RT Journal Article
T1 Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure
A1 García-Delgado, Manuel
A1 Touma-Fernández, Ángel
A1 Chamorro-Marín, Virginia
A1 Ruiz-Aguilar, Antonio
A1 Aguilar-Alonso, Eduardo
A1 Fernández-Mondéjar, Enrique
K1 Animales
K1 Agua Pulmonar Extravascular
K1 Hemodinámica
K1 Modelos Animales
K1 Respiración con Presión Positiva
K1 Edema Pulmonar
K1 Porcinos
K1 Resultado del Tratamiento
AB INTRODUCTIONThe objectives were to characterize alveolar fluid clearance (AFC) in pigs with normal lungs and to analyze the effect of immediate application of positive end-expiratory pressure (PEEP).METHODSAnimals (n = 25) were mechanically ventilated and divided into four groups: small edema (SE) group, producing pulmonary edema (PE) by intratracheal instillation of 4 ml/kg of saline solution; small edema with PEEP (SE + PEEP) group, same as previous but applying PEEP of 10 cmH2O; large edema (LE) group, producing PE by instillation of 10 ml/kg of saline solution; and large edema with PEEP (LE + PEEP) group, same as LE group but applying PEEP of 10 cmH2O. AFC was estimated from differences in extravascular lung water values obtained by transpulmonary thermodilution method.RESULTSAt one hour, AFC was 19.4% in SE group and 18.0% in LE group. In the SE + PEEP group, the AFC rate was higher at one hour than at subsequent time points and higher than in the SE group (45.4% vs. 19.4% at one hour, P < 0.05). The AFC rate was also significantly higher in the LE + PEEP than in the LE group at three hours and four hours.CONCLUSIONSIn this pig model, the AFC rate is around 20% at one hour and around 50% at four hours, regardless of the amount of edema, and is increased by the application of PEEP.
PB BioMed Central
SN 1364-8535
YR 2010
FD 2010-03-16
LK http://hdl.handle.net/10668/597
UL http://hdl.handle.net/10668/597
LA en
NO García-Delgado M,  Touma-Fernández A, Chamorro-Marín V,  Ruiz-Aguilar A, Aguilar-Alonso E , Fernández-Mondéjar E.Alveolar fluid clearance in healthy pigs and influence of positive end-expiratory pressure.Crit Care. 2010;14(2):R36
NO Journal Article;
DS RISalud
RD Apr 12, 2025