RT Journal Article
T1 Clinical Characteristics and Risk Factors of Respiratory Failure in a Cohort of Young Patients Requiring Hospital Admission with SARS-CoV2 Infection in Spain: Results of the Multicenter SEMI-COVID-19 Registry.
A1 Diaz-Simon, Raquel
A1 Lalueza, Antonio
A1 Lora-Tamayo, Jaime
A1 Rubio-Rivas, Manuel
A1 Llamazares-Mendo, Cristina
A1 Taboada-Martinez, Maria Luisa
A1 Meéndez, Cristina Asencio
A1 Pesqueira-Fontan, Paula M
A1 Fernandez-Cruz, Ana
A1 Romero-Cabrera, Juan Luis
A1 Cortes-Rodriguez, Begoña
A1 Espinar-Rubio, Aurora
A1 Serrano-Romero-de-Avila, Vicente
A1 Garcia-Garcia, Gema Maria
A1 Osorio, Luis Cabeza
A1 Gonzalez-Fernandez, Maria
A1 Gonzalez-Noya, Amara
A1 Bernabeu-Wittel, Maximo
A1 Arnalich-Fernandez, Francisco
A1 Martinez-Sempere, Veronica
A1 Artero, Arturo
A1 Loureiro-Amigo, Jose
A1 Gomez-Huelgas, Ricardo
A1 Anton-Santos, Juan Miguel
A1 Lumbreras, Carlos
K1 COVID-19
K1 SARS-CoV2
K1 Hyponatremia
K1 Obesity
K1 Respiratory failure
K1 Young
AB Age is a risk factor for COVID severity. Most studies performed in hospitalized patients with SARS-CoV2 infection have shown an over-representation of older patients and consequently few have properly defined COVID-19 in younger patients who require hospital admission. The aim of the present study was to analyze the clinical characteristics and risk factors for the development of respiratory failure among young (18 to 50 years) hospitalized patients with COVID-19. This retrospective nationwide cohort study included hospitalized patients from 18 to 50 years old with confirmed COVID-19 between March 1, 2020, and July 2, 2020. All patient data were obtained from the SEMI-COVID Registry. Respiratory failure was defined as the ratio of partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2 ratio) ≤200 mmHg or the need for mechanical ventilation and/or high-flow nasal cannula or the presence of acute respiratory distress syndrome. During the recruitment period, 15,034 patients were included in the SEMI-COVID-19 Registry, of whom 2327 (15.4%) were younger than 50 years. Respiratory failure developed in 343 (14.7%), while mortality occurred in 2.3%. Patients with respiratory failure showed a higher incidence of major adverse cardiac events (44 (13%) vs 14 (0.8%), p320 U/I (OR, 1.69; 95% CI, 1.18 to 2.42; p=0.0039), AST >35 mg/dL (OR, 1.74; 95% CI, 1.2 to 2.52; p=0.003), sodium 35 mg/dL (OR, 1.74; 95% CI, 1.2 to 2.52; p=0.003), sodium 8 mg/dL (OR, 2.42; 95% CI, 1.72 to 3.41; p Young patients with COVID-19 requiring hospital admission showed a notable incidence of respiratory failure. Obesity, SAHS, alcohol abuse, and certain laboratory parameters were independently associated with the development of this complication. Patients who suffered respiratory failure had a higher mortality and a higher incidence of major cardiac events, venous thrombosis, and hospital stay.
PB Oxford University Press
YR 2021
FD 2021-08-11
LK http://hdl.handle.net/10668/18359
UL http://hdl.handle.net/10668/18359
LA en
NO Ramos-Rincon JM, Buonaiuto V, Ricci M, Martín-Carmona J, Paredes-Ruíz D, Calderón-Moreno M, et al. Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized With COVID-19 in Spain. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):e28-e37
DS RISalud
RD Apr 7, 2025