RT Journal Article
T1 Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study.
A1 Martin-Piedra, Laura
A1 Alcala-Diaz, Juan F
A1 Gutierrez-Mariscal, Francisco M
A1 Arenas de Larriva, Antonio P
A1 Romero-Cabrera, Juan L
A1 Torres-Peña, Jose D
A1 Caballero-Villarraso, Javier
A1 Luque, Raul M
A1 Perez-Martinez, Pablo
A1 Lopez-Miranda, Jose
A1 Delgado-Lista, Javier
K1 Mediterranean diet
K1 coronary patients
K1 diet intervention
K1 fatty liver index
K1 low-fat diet
K1 metabolically healthy obese
K1 metabolically unhealthy obese
K1 obesity metabolic phenotypes
AB Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p  A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes.
YR 2021
FD 2021-11-12
LK https://hdl.handle.net/10668/25862
UL https://hdl.handle.net/10668/25862
LA en
DS RISalud
RD Apr 11, 2025