RT Journal Article
T1 Metabolic Targets of Coenzyme Q10 in Mitochondria.
A1 Hidalgo-Gutierrez, Agustin
A1 Gonzalez-Garcia, Pilar
A1 Diaz-Casado, Maria Elena
A1 Barriocanal-Casado, Eliana
A1 Lopez-Herrador, Sergio
A1 Quinzii, Catarina M
A1 Lopez, Luis C
K1 OxPhos
K1 coenzyme Q10
K1 mitochondria
K1 one-carbon metabolism
K1 proline metabolism
K1 sulfide metabolism
K1 super-complexes
K1 ubiquinol-10
K1 ubiquinone-10
AB Coenzyme Q10 (CoQ10) is classically viewed as an important endogenous antioxidant and key component of the mitochondrial respiratory chain. For this second function, CoQ molecules seem to be dynamically segmented in a pool attached and engulfed by the super-complexes I + III, and a free pool available for complex II or any other mitochondrial enzyme that uses CoQ as a cofactor. This CoQ-free pool is, therefore, used by enzymes that link the mitochondrial respiratory chain to other pathways, such as the pyrimidine de novo biosynthesis, fatty acid β-oxidation and amino acid catabolism, glycine metabolism, proline, glyoxylate and arginine metabolism, and sulfide oxidation metabolism. Some of these mitochondrial pathways are also connected to metabolic pathways in other compartments of the cell and, consequently, CoQ could indirectly modulate metabolic pathways located outside the mitochondria. Thus, we review the most relevant findings in all these metabolic functions of CoQ and their relations with the pathomechanisms of some metabolic diseases, highlighting some future perspectives and potential therapeutic implications.
PB MDPI AG
SN 2076-3921
YR 2021
FD 2021-03-23
LK http://hdl.handle.net/10668/17525
UL http://hdl.handle.net/10668/17525
LA en
NO Hidalgo-Gutiérrez A, González-García P, Díaz-Casado ME, Barriocanal-Casado E, López-Herrador S, Quinzii C, et al. Metabolic Targets of Coenzyme Q10 in Mitochondria. Antioxidants (Basel). 2021 Mar 26;10(4):520.
NO his work was supported by grants from Ministerio de Ciencia e Innovación, Spain, and the ERDF (RTI2018-093503-B-100), the Muscular Dystrophy Association (MDA-602322). C.M.Q. is supported by the Department of Defense (DOD) grant PR190511. A.H.-G. and P.G.-G. are ‘FPU fellows’ from the Ministerio de Universidades, Spain. S.L.-H. is supported by the “becas de colaboración” from the Ministerio de Universidades, Spain. E.B.-C. is supported by the Consejería de Salud, Junta de Andalucía, Spain.
DS RISalud
RD Apr 12, 2025