RT Journal Article
T1 Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome.
A1 Konieczna, Jadwiga
A1 Fiol, Miguel
A1 Colom, Antoni
A1 Martínez-Gonzalez, Miguel Angel
A1 Salas-Salvado, Jordi
A1 Corella, Dolores
A1 Soria-Florido, Maria Trinidad
A1 Martinez, J Alfredo
A1 Alonso-Gomez, Angel M
A1 Wärnberg, Julia
A1 Vioque, Jesus
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Bernal-Lopez, M Rosa
A1 Lapetra, Jose
A1 Serra-Majem, Lluís
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A
A1 Martin-Sanchez, Vicente
A1 Pinto, Xavier
A1 Gaforio, Jose J
A1 Matia-Martin, Pilar
A1 Vidal, Josep
A1 Vazquez, Clotilde
A1 Daimiel, Lidia
A1 Ros, Emilio
A1 Bes-Rastrollo, Maira
A1 Pascual, Maria
A1 Sorli, Jose V
A1 Goday, Albert
A1 Zulet, Maria Angeles
A1 Moreno-Rodriguez, Anai
A1 Carmona-Gonzalez, Francisco Jesus
A1 Valls-Enguix, Rafael
A1 Janer, Juana M
A1 Garcia-Rios, Antonio
A1 Casas, Rosa
A1 Gomez-Perez, Ana M
A1 Santos-Lozano, Jose Manuel
A1 Basterra-Gortari, F Javier
A1 Martinez, Maria Angeles
A1 Ortega-Azorin, Carolina
A1 Bayo, Joan
A1 Abete, Itziar
A1 Salaverria-Lete, Itziar
A1 Ruiz-Canela, Miguel
A1 Babio, Nancy
A1 Carres, Lourdes
A1 Romaguera, Dora
K1 Fatty liver index
K1 Hepatic steatosis index
K1 Liver health markers
K1 Metabolic syndrome
K1 Ultra-processed foods
AB Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (β 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-valuess < 0.001). These associations persisted statistically significant afteradjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS
PB MDPI
YR 2022
FD 2022-09-27
LK http://hdl.handle.net/10668/21509
UL http://hdl.handle.net/10668/21509
LA en
NO Konieczna J, Fiol M, Colom A, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome. Nutrients. 2022 Oct 5;14(19):414
DS RISalud
RD Apr 7, 2025