RT Journal Article
T1 Benefits of a Single Dose of Betamethasone in Imminent Preterm Labour.
A1 Saldaña-Garcia, Natalia
A1 Espinosa-Fernandez, Maria Gracia
A1 Gomez-Robles, Celia
A1 Postigo-Jimenez, Antonio Javier
A1 Bello, Nicholas
A1 Rius-Diaz, Francisca
A1 Sanchez-Tamayo, Tomas
K1 Antenatal corticosteroids
K1 Betamethasone
K1 Mortality
K1 Preterm infant
K1 Respiratory distress syndrome
AB A complete course of prenatal corticosteroids reduces the possibility of morbimortality and neonatal respiratory distress syndrome (RDS). Occasionally, it is not possible to initiate or complete the maturation regimen, and the preterm neonate is born in a non-tertiary hospital. This study aimed to assess the effects of a single dose of betamethasone within 3 h before delivery on serious outcomes (mortality and serious sequelae) and RDS in preterm neonates born in tertiary vs. non-tertiary hospitals. Preterm neonates who were  A total of 76 preterm neonates were included. A decrease in serious outcomes was found in the PM group in comparison to the NM group (OR = 0.2; 95%CI (0.07-0.9)), as well as reduced need for mechanical ventilation (54% vs. 68%). The mean time between maternal admission and birth was similar in both cohorts. The mean time from the administration of betamethasone to delivery was 1 h in the PM cohort. With regard to births in NICU-IIIC, the PM group performed better in terms of serious outcomes (32% vs. 45%) and the duration of mechanical ventilation (117.75 vs. 132.18 h) compared to the NM group. In neonates born in non-tertiary hospitals with PM in comparison to the NM group, a trend towards a reduced serious outcome (28.5% vs. 62.2%) and a decreased need for mechanical ventilation (OR = 0.09; 95%CI (0.01-0.8)) and maximum FiO2 (p = 0.01) was observed. A single dose of betamethasone up to 3 h antepartum may reduce the rate of serious outcomes and the severity of neonatal RDS, especially in non-tertiary hospitals.
PB MDPI
SN 2077-0383
YR 2021
FD 2021-12-21
LK http://hdl.handle.net/10668/21223
UL http://hdl.handle.net/10668/21223
LA en
NO Saldaña-García N, Espinosa-Fernández MG, Gómez-Robles C, Postigo-Jiménez AJ, Bello N, Rius-Díaz F, et al. Benefits of a Single Dose of Betamethasone in Imminent Preterm Labour. J Clin Med. 2021 Dec 21;11(1):20
DS RISalud
RD Apr 18, 2025