RT Journal Article
T1 Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer
A1 Mesas, Cristina
A1 Martínez, Rosario
A1 Ortíz, Raúl
A1 Galisteo, Milagros
A1 López-Jurado, María
A1 Cabeza, Laura
A1 Perazzoli, Gloria
A1 Melguizo, Consolación
A1 Porres, Jesús M.
A1 Prados, Jose
K1 Colon cancer
K1 Euphorbia lathyris
K1 Ethanolic extract
K1 Apoptosis
K1 Antiangiogenic effect
K1 Cancer stem cells
K1 Neoplasias del colon
K1 Proliferación celular
K1 Etanol
K1 Polifenoles
AB The seeds of Euphorbia lathyris have been used in traditional medicine to treat various medical conditions. However, neither all of their active biocompounds nor the molecular mechanisms underlying their therapeutic effects have been described. A new ethanolic extract of defatted flour from mature seeds of Euphorbia lathyris showed a high total polyphenol content and significant antioxidant activity. Chromatographic analysis showed that esculetin, euphorbetin, gaultherin, and kaempferol-3-rutinoside were the most abundant polyphenolic bioactive compounds. Antiproliferative assays showed a high and selective antitumor activity against colon cancer cell lines (T84 and HCT-15). In addition, a significant antiproliferative activity against glioblastoma multiforme cells was also demonstrated. Its mechanism of action to induce cell death was mediated by the overexpression of caspases 9, 3, and 8, and by activation of autophagy. Interestingly, a reduction in the migration capacity of colon cancer cells and a significant antiangiogenic effect on human umbilical vein endothelial cells were also demonstrated. Finally, the extract significantly reduced the subpopulations of cancer stem cells. This extract could be the basis to develop new therapeutic strategies for the treatment of colon cancer, although further experiments will be necessary to determine its in vivo effects.
PB MDPI
YR 2021
FD 2021-02-09
LK http://hdl.handle.net/10668/3518
UL http://hdl.handle.net/10668/3518
LA en
NO Mesas C, Martínez R, Ortíz R, Galisteo M, López-Jurado M, Cabeza L, et al.. Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer. Nutrients. 2021 13(2):566.
NO Results have been protected by the patent application Ministerio de Ciencia e Innovación P202030454.
DS RISalud
RD Apr 11, 2025