RT Journal Article T1 Oral Photoprotection: Effective Agents and Potential Candidates. A1 Parrado, Concepción A1 Philips, Neena A1 Gilaberte, Yolanda A1 Juarranz, Angeles A1 González, Salvador K1 dietary botanical K1 oral photoprotection K1 oxidative stress K1 photocarcinogenesis K1 photodamage AB Electromagnetic radiation in the ultraviolet, visible, and infrared ranges produces biologic effects in humans. Where some of these effects are beneficial, others are harmful to the skin, particularly those stemming from ultraviolet radiation (UVR). Pharmacological photoprotection can be topical or systemic. Systemic photoprotection is often administered orally, complementing topical protection. New and classic oral agents (e.g., essential micronutrients as vitamins, minerals, polyphenols, carotenoids) are endowed with photoprotective and anti-photocarcinogenic properties. These substances bear the potential to increase systemic protection against the effects of electromagnetic radiation in the UV, visible, and infrared ranges. Protective mechanisms vary and include anti-oxidant, anti-inflammatory, and immunomodulatory effects. As such, they provide protection against UVR and prevent photo-induced carcinogenesis and aging. In this review, we present state of the art approaches regarding the photoprotective effects of vitamins and vitamin derivatives, dietary botanical, and non-botanical agents. A growing body of data supports the beneficial effects of oral photoprotection on the health of the skin. More studies will likely confirm and expand the positive impact of oral dietary botanicals as complementary measures for photoprotection. SN 2296-858X YR 2018 FD 2018-06-26 LK https://hdl.handle.net/10668/24483 UL https://hdl.handle.net/10668/24483 LA en DS RISalud RD Apr 6, 2025