RT Journal Article
T1 The relationship between blood pressure and risk of renal cell carcinoma.
A1 Alcala, Karine
A1 Mariosa, Daniela
A1 Smith-Byrne, Karl
A1 Nasrollahzadeh Nesheli, Dariush
A1 Carreras-Torres, Robert
A1 Ardanaz Aicua, Eva
A1 Bondonno, Nicola P
A1 Bonet, Catalina
A1 Brunström, Mattias
A1 Bueno-de-Mesquita, Bas
A1 Chirlaque, María-Dolores
A1 Christakoudi, Sofia
A1 Heath, Alicia K
A1 Kaaks, Rudolf
A1 Katzke, Verena
A1 Krogh, Vittorio
A1 Ljungberg, Börje
A1 Martin, Richard M
A1 May, Anne
A1 Melander, Olle
A1 Palli, Domenico
A1 Rodriguez-Barranco, Miguel
A1 Sacerdote, Carlotta
A1 Stocks, Tanja
A1 Tjønneland, Anne
A1 Travis, Ruth C
A1 Vermeulen, Roel
A1 Chanock, Stephen
A1 Purdue, Mark
A1 Weiderpass, Elisabete
A1 Muller, David
A1 Brennan, Paul
A1 Johansson, Mattias
K1 Mendelian randomization
K1 RCC
K1 diastolic blood pressure
K1 kidney cancer
K1 systolic blood pressure
AB The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail. Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP. In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP. The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP.
PB Oxford University Press
YR 2022
FD 2022-03-07
LK http://hdl.handle.net/10668/19800
UL http://hdl.handle.net/10668/19800
LA en
NO Alcala K, Mariosa D, Smith-Byrne K, Nasrollahzadeh Nesheli D, Carreras-Torres R, Ardanaz Aicua E, et al. The relationship between blood pressure and risk of renal cell carcinoma. Int J Epidemiol. 2022 Aug 10;51(4):1317-1327
DS RISalud
RD Apr 8, 2025