RT Journal Article
T1 Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries.
A1 Larrañaga, Nerea
A1 Sanchez-Perez, Maria-Jose
A1 Ardanaz, Eva
A1 Felipe, Saray
A1 Marcos-Gragera, Rafael
A1 Ramos, María
A1 Carulla, Marià
A1 Chirlaque, M Dolores
A1 Argüelles, Marcial V
A1 Martos, Carmen
A1 Mateo, Antonio
A1 Peris-Bonet, Rafael
K1 Cancer
K1 Solid tumour
K1 Childhood
K1 Adolescents
K1 Population-based study
K1 Incidence
K1 Spain
K1 Neoplasias
K1 Adolescente
K1 Incidencia
K1 Niño
K1 España
AB OBJECTIVETo describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain.METHODSCases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for the period 1983-2007 and trends were evaluated using Joinpoint regression analysis.RESULTSThe studied tumour groups accounted for 36% of total childhood cancers and 47.6% of those diagnosed in adolescence with annual rates per million of 53.5 and 89.3 respectively. In children 0 to 14 years of age, Neuroblastoma (NB) was the commonest (7.8%) followed by Soft-tissue sarcomas (STS) (6.3%), bone tumours (BT) (6.2%) and renal tumours (RT) (4.5%). NB was the most frequently diagnosed tumour before the 5th birthday, while STS and BT were the commonest at 5-9 years of age, and BT and Carcinoma and other epithelial tumours (COET) at 10-14. COET presented the highest incidence in adolescents, followed by germ-cell tumours (GCT), BT and STS. These four diagnostic groups accounted for 94% of total non-CNS solid tumours, in adolescents. Overall incidence rates increased significantly in children up to 1996 with an annual percentage change (APC) of 2.6% (95%CI: 1.7; 3.6). NB and COET showed significant time trend (APCs: 1.4% and 3.8% respectively) while other tumour groups such as RT, STS, BT or GCT had no significant changes over time. A significant increase was present in NB under the age of 5 and in BT and STS in children aged 10-14 years. In adolescents there were significant increases for all tumours combined (APC=2.7; 95%CI: 1.8-3.6) and for STS, GCT and COET (APCs: 3.2%, 4.4% and 3.5% respectively), while other tumour groups such as hepatic tumours, BT or thyroid carcinomas showed a decreasing trend or no increase.CONCLUSIONSOverall, the incidence of the studied cancers in children increased along the period 1983-1996 with no posterior significant rise, while the incidence in adolescents increased significantly over the whole period 1983-2007. Several specific tumour groups showed significant rises or decrements in childhood or adolescence, although the small number of cases precludes showing significant trends or inflexion points.
PB Ivyspring International Publisher
YR 2016
FD 2016-01-10
LK http://hdl.handle.net/10668/2367
UL http://hdl.handle.net/10668/2367
LA en
NO Larrañaga N, Sanchez MJ, Ardanaz E, Felipe S, Marcos-Gragera R, Ramos M, et al. Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries. J Cancer 2016; 7(3):335-43
NO Journal Article;
DS RISalud
RD Apr 9, 2025