RT Journal Article
T1 Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart.
A1 Barriales, Diego
A1 Martín-Ruiz, Itziar
A1 Carreras-Gonzalez, Ana
A1 Montesinos-Robledo, Marta
A1 Azkargorta, Mikel
A1 Iloro, Ibon
A1 Escobes, Iraide
A1 Martin-Mateos, Teresa
A1 Atondo, Estibaliz
A1 Palacios, Ainhoa
A1 Gonzalez-Lopez, Monika
A1 Barcena, Laura
A1 Cortáazar, Ana R
A1 Cabrera, Diana
A1 Peña-Cearra, Ainize
A1 van-Liempd, Sebastiaan M
A1 Falcon-Perez, Juan M
A1 Pascual-Itoiz, Miguel A
A1 Flores, Juana Maria
A1 Abecia, Leticia
A1 Pellon, Aize
A1 Martinez-Chantar, Maria Luz
A1 Aransay, Ana M
A1 Pascual, Alberto
A1 Elortza, Felix
A1 Berra, Edurne
A1 Lavin, Jose Luis
A1 Rodriguez, Hector
A1 Anguita, Juan
K1 Animals
K1 Cardiomyopathies
K1 Endocarditis, Bacterial
K1 HEK293 Cells
K1 Immunologic Memory
K1 Macrophage Activation
K1 Male
K1 Myocytes, Cardiac
AB Lyme carditis is an extracutaneous manifestation of Lyme disease characterized by episodes of atrioventricular block of varying degrees and additional, less reported cardiomyopathies. The molecular changes associated with the response to Borrelia burgdorferi over the course of infection are poorly understood. Here, we identify broad transcriptomic and proteomic changes in the heart during infection that reveal a profound down-regulation of mitochondrial components. We also describe the long-term functional modulation of macrophages exposed to live bacteria, characterized by an augmented glycolytic output, increased spirochetal binding and internalization, and reduced inflammatory responses. In vitro, glycolysis inhibition reduces the production of tumor necrosis factor (TNF) by memory macrophages, whereas in vivo, it produces the reversion of the memory phenotype, the recovery of tissue mitochondrial components, and decreased inflammation and spirochetal burdens. These results show that B. burgdorferi induces long-term, memory-like responses in macrophages with tissue-wide consequences that are amenable to be manipulated in vivo.
PB Public Library of Science
YR 2021
FD 2021-01-04
LK http://hdl.handle.net/10668/16906
UL http://hdl.handle.net/10668/16906
LA en
NO Barriales D, Martín-Ruiz I, Carreras-González A, Montesinos-Robledo M, Azkargorta M, Iloro I, et al. Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart. PLoS Biol. 2021 Jan 4;19(1):e3001062.
DS RISalud
RD Apr 11, 2025