RT Journal Article
T1 Reproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure.
A1 Alcantara, Juan M A
A1 Sanchez-Delgado, Guillermo
A1 Jurado-Fasoli, Lucas
A1 Galgani, Jose E
A1 Labayen, Idoia
A1 Ruiz, Jonatan R
K1 Glucose tolerance
K1 Indirect calorimetry
K1 Metabolic cart
K1 Postprandial metabolism
K1 Reliability
AB Metabolic flexibility (MetF), which is a surrogate of metabolic health, can be assessed by the change in the respiratory exchange ratio (RER) in response to an oral glucose tolerance test (OGTT). We aimed to determine the day-to-day reproducibility of the energy expenditure (EE) and RER response to an OGTT, and whether a simulation-based postcalorimetric correction of metabolic cart readouts improves day-to-day reproducibility. The EE was assessed (12 young adults, 6 women, 27 ± 2 years old) using an Omnical metabolic cart (Maastricht Instruments, Maastricht, The Netherlands) after an overnight fast (12 h) and after a 75-g oral glucose dose on 2 separate days (48 h). On both days, we assessed EE in 7 periods (one 30-min baseline and six 15-min postprandial). The ICcE was performed immediately after each recording period, and capillary glucose concentration (using a digital glucometer) was determined. We observed a high day-to-day reproducibility for the assessed RER (coefficients of variation [CV]  Our study demonstrates that the energy metabolism response to an OGTT is poorly reproducible (CVs > 20%) even using a very accurate metabolic cart. Furthermore, the postcalorimetric correction procedure did not influence the day-to-day reproducibility. Trial registration NCT04320433; March 25, 2020.
PB Springer Medizin
YR 2022
FD 2022-08-03
LK http://hdl.handle.net/10668/19930
UL http://hdl.handle.net/10668/19930
LA en
NO Alcantara JMA, Sanchez-Delgado G, Jurado-Fasoli L, Galgani JE, Labayen I, Ruiz JR. Reproducibility of the energy metabolism response to an oral glucose tolerance test: influence of a postcalorimetric correction procedure. Eur J Nutr. 2023 Feb;62(1):351-361
NO Funding for open access charge: Universidad de Granada / CBUA. Supported by the Spanish Ministry of Economy and Competitiveness via Retos de la Sociedad grant DEP2016-79512-R (to JRR), and European Regional Development Funds (ERDF); Spanish Ministry of Education grant (FPU15/04059 to JMAA; and FPU19/01609 to LJ-F); the University of Granada Plan Propio de Investigación 2016-Excellence actions: Unit of Excellence on Exercise and Health (to JRR)—Plan Propio de Investigación 2018 and 2020 Programa Contratos-Puente and Programa Perfeccionamiento de Doctores (to GS-D, and to JMAA respectively); Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades grant SOMM17/6107/UGR (to JRR) via the ERDF; and the Fundación Alfonso Martín Escudero (to GS-D).
DS RISalud
RD Apr 10, 2025