TY - JOUR AU - Martín-Escolano, Rubén AU - Aguilera-Venegas, Benjamín AU - Marín, Clotilde AU - Martín-Montes, Álvaro AU - Martín-Escolano, Javier AU - Medina-Carmona, Encarnación AU - Arán, Vicente J AU - Sánchez-Moreno, Manuel PY - 2018 DO - 10.1002/cmdc.201800512 UR - http://hdl.handle.net/10668/12822 T2 - ChemMedChem AB - Chagas disease, a neglected tropical disease caused by infection with the protozoan parasite Trypanosoma cruzi, is a potentially life-threatening illness that affects 5-8 million people in Latin America, and more than 10 million people worldwide. It... LA - en KW - Chagas disease KW - Trypanosoma cruzi KW - antiprotozoal agents KW - drug discovery KW - nitroheterocycles KW - Animals KW - Chagas Disease KW - Chlorocebus aethiops KW - DNA KW - Enzyme Inhibitors KW - Ethylamines KW - Female KW - Indazoles KW - Membrane Potential, Mitochondrial KW - Mice, Inbred BALB C KW - Neglected Diseases KW - RNA KW - Superoxide Dismutase KW - Trypanocidal Agents KW - Trypanosoma cruzi KW - Vero Cells TI - Synthesis and Biological in vitro and in vivo Evaluation of 2-(5-Nitroindazol-1-yl)ethylamines and Related Compounds as Potential Therapeutic Alternatives for Chagas Disease. TY - research article VL - 13 ER -