RT Journal Article
T1 Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases.
A1 Pardillo-Diaz, Ricardo
A1 Perez-Garcia, Patricia
A1 Castro, Carmen
A1 Nunez-Abades, Pedro
A1 Carrascal, Livia
K1 Hyperexcitability
K1 Motor neuron
K1 Neurodegenerative diseases
K1 Oxidative stress
AB Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological processes appear to be similar, suggesting common neurodegenerative pathways. It is well known that oxidative stress and the production of reactive oxygen radicals plays a key role in neuronal cell damage. It has been proposed that this stress, among other mechanisms, could contribute to neuronal degeneration and might be one of the factors triggering the development of these pathologies. Another common feature in most neurodegenerative diseases is neuron hyperexcitability, an aberrant electrical activity. This review, focusing mainly on primary motor cortex pyramidal neurons, critically evaluates the idea that oxidative stress and inflammation may be involved in neurodegeneration via their capacity to increase membrane excitability.
PB MDPI
SN 2076-3921
YR 2022
FD 2022-07-29
LK http://hdl.handle.net/10668/20784
UL http://hdl.handle.net/10668/20784
LA en
NO Pardillo-Díaz R, Pérez-García P, Castro C, Nunez-Abades P, Carrascal L. Oxidative Stress as a Potential Mechanism Underlying Membrane Hyperexcitability in Neurodegenerative Diseases. Antioxidants (Basel). 2022 Aug 2;11(8):1511
DS RISalud
RD Apr 5, 2025