RT Journal Article
T1 Edge vascular response after polymer-free vs. polymer-based paclitaxel-eluting stent implantation.
A1 Otsuki, Shuji
A1 Shiratori, Yoshitaka
A1 Brugaletta, Salvatore
A1 Cola, Clarissa
A1 García Del Blanco, Bruno
A1 Ruiz-Salmeron, Rafael
A1 Díaz, José Francisco
A1 Pinar, Eduardo
A1 Martí, Vicens
A1 García-Picart, Juan
A1 Martín-Yuste, Victoria
A1 Sabaté, Manel
K1 Drug-eluting stent
K1 Intravascular ultrasound
K1 Edge vascular response
K1 Polymer-based paclitaxel-eluting stent
K1 Polymer-free paclitaxel-eluting stent
K1 Stents Liberadores de Fármacos
K1 Estudios de Seguimiento
K1 Paclitaxel
K1 Estudios Prospectivos
K1 Ultrasonografía Intervencional
AB BACKGROUNDIt is unknown if lack of polymer can provoke a different edge response in drug-eluting stents. The aim of this study was to compare edge vascular response between polymer-free paclitaxel-eluting stent (PF-PES) and polymer-based paclitaxel-eluting stents (PB-PES). METHODS AND RESULTS: A total of 165 eligible patients undergoing percutaneous coronary intervention were prospectively randomized 1:1 to receive either PF-PES or PB-PES. Those patients with paired intravascular ultrasound (IVUS) after procedure and at 9-month follow-up were included in this analysis.Seventy-six patients with 84 lesions, divided into PB-PES (38 patients, 41 lesions) and PF-PES groups (38 patients, 43 lesions) had paired post-procedure and 9-month follow-up IVUS and were therefore included in this substudy. There was a significant lumen decrease at the proximal edge of PF-PES (from 9.02±3.06 mm(2)to 8.47±3.05 mm(2); P=0.040), and a significant plaque increase at the distal edges of PF-PES (from 4.39±2.73 mm(2)to 4.78±2.63 mm(2); P=0.004). At the distal edge there was a significant plaque increase in the PF-PES compared to PB-PES (+8.0% vs. -0.6%, respectively; P=0.015) with subsequent lumen reduction (-5.2% vs. +6.0%, respectively; P=0.024).CONCLUSIONSPF-PES had significant plaque increase and lumen reduction at the distal edge as compared to PB-PES, probably due to difference in polymer-based drug-release kinetics between the 2 platforms.
PB Japanese Circulation Society
SN 1346-9843
YR 2014
FD 2014-09-22
LK http://hdl.handle.net/10668/2030
UL http://hdl.handle.net/10668/2030
LA en
NO Otsuki S, Shiratori Y, Brugaletta S, Cola C, García Del Blanco B, Ruiz-Salmeron R, et al. Edge vascular response after polymer-free vs. polymer-based paclitaxel-eluting stent implantation. Circ. J. 2014; 78(11):2657-64
NO Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial;
DS RISalud
RD Apr 17, 2025