RT Journal Article
T1 Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
A1 de Rojas, Itziar
A1 Hernandez, Isabel
A1 Montrreal, Laura
A1 Quintela, Ines
A1 Calero, Miguel
A1 Royo, Jose Luis
A1 Huerto Vilas, Raquel
A1 Gonzalez-Perez, Antonio
A1 Franco-Macias, Emilio
A1 Macias, Juan
A1 Menendez-Gonzalez, Manuel
A1 Frank-Garcia, Ana
A1 Diez-Fairen, Monica
A1 Lage, Carmen
A1 Garcia-Madrona, Sebastian
A1 Aguilera, Nuria
A1 Garcia-Gonzalez, Pablo
A1 Puerta, Raquel
A1 Sotolongo-Grau, Oscar
A1 Alonso-Lana, Silvia
A1 Rabano, Alberto
A1 Arias Pastor, Alfonso
A1 Pastor, Ana Belen
A1 Corma-Gomez, Anais
A1 Martin Montes, Angel
A1 Martinez Rodriguez, Carmen
A1 Buiza-Rueda, Dolores
A1 Perinan, Maria Teresa
A1 Rodriguez-Rodriguez, Eloy
A1 Alvarez, Ignacio
A1 Allende, Irene Rosas
A1 Pineda, Juan A. A.
A1 Bernal Sanchez-Arjona, Maria
A1 Fernandez-Fuertes, Marta
A1 Mendoza, Silvia
A1 del Ser, Teodoro
A1 Garcia-Ribas, Guillermo
A1 Sanchez-Juan, Pascual
A1 Pastor, Pau
A1 Bullido, Maria J.
A1 Alvarez, Victoria
A1 Real, Luis M. M.
A1 Mir, Pablo
A1 Pinol-Ripoll, Gerard
A1 Garcia-Alberca, Jose Maria
A1 Medina, Miguel
A1 Orellana, Adelina
A1 Butler, Chris R. R.
A1 Marquie, Marta
A1 Saez, Maria Eugenia
A1 Carracedo, Angel
A1 Tarraga, Lluis
A1 Boada, Merce
A1 Ruiz, Agustin
K1 SARS-CoV-2
K1 COVID-19
K1 GWAS
K1 GR@ACE
K1 DEGESCO
K1 dementia
K1 APOE
K1 Apolipoprotein-e
K1 Genotype
K1 Disease
AB Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
PB Mdpi
YR 2021
FD 2021-12-01
LK https://hdl.handle.net/10668/27289
UL https://hdl.handle.net/10668/27289
LA en
DS RISalud
RD Apr 11, 2025