%0 Journal Article
%A de Rojas, Itziar
%A Hernandez, Isabel
%A Montrreal, Laura
%A Quintela, Ines
%A Calero, Miguel
%A Royo, Jose Luis
%A Huerto Vilas, Raquel
%A Gonzalez-Perez, Antonio
%A Franco-Macias, Emilio
%A Macias, Juan
%A Menendez-Gonzalez, Manuel
%A Frank-Garcia, Ana
%A Diez-Fairen, Monica
%A Lage, Carmen
%A Garcia-Madrona, Sebastian
%A Aguilera, Nuria
%A Garcia-Gonzalez, Pablo
%A Puerta, Raquel
%A Sotolongo-Grau, Oscar
%A Alonso-Lana, Silvia
%A Rabano, Alberto
%A Arias Pastor, Alfonso
%A Pastor, Ana Belen
%A Corma-Gomez, Anais
%A Martin Montes, Angel
%A Martinez Rodriguez, Carmen
%A Buiza-Rueda, Dolores
%A Perinan, Maria Teresa
%A Rodriguez-Rodriguez, Eloy
%A Alvarez, Ignacio
%A Allende, Irene Rosas
%A Pineda, Juan A. A.
%A Bernal Sanchez-Arjona, Maria
%A Fernandez-Fuertes, Marta
%A Mendoza, Silvia
%A del Ser, Teodoro
%A Garcia-Ribas, Guillermo
%A Sanchez-Juan, Pascual
%A Pastor, Pau
%A Bullido, Maria J.
%A Alvarez, Victoria
%A Real, Luis M. M.
%A Mir, Pablo
%A Pinol-Ripoll, Gerard
%A Garcia-Alberca, Jose Maria
%A Medina, Miguel
%A Orellana, Adelina
%A Butler, Chris R. R.
%A Marquie, Marta
%A Saez, Maria Eugenia
%A Carracedo, Angel
%A Tarraga, Lluis
%A Boada, Merce
%A Ruiz, Agustin
%T Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
%D 2021
%U https://hdl.handle.net/10668/27289
%X Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
%K SARS-CoV-2
%K COVID-19
%K GWAS
%K GR@ACE
%K DEGESCO
%K dementia
%K APOE
%K Apolipoprotein-e
%K Genotype
%K Disease
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