RT Journal Article
T1 Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype
A1 Lope, Virginia
A1 Guerrero-Zotano, Ángel
A1 Casas, Ana
A1 Baena-Cañada, José Manuel
A1 Bermejo, Begoña
A1 Pérez-Gómez, Beatriz
A1 Criado-Navarro, Inmaculada
A1 Antolín, Silvia
A1 Sánchez-Rovira, Pedro
A1 Ramos-Vázquez, Manuel
A1 Antón, Antonio
A1 Castelló, Adela
A1 García-Saénz, José Ángel
A1 Muñoz, Montserrat
A1 de Juan, Ana
A1 Andrés, Raquel
A1 Llombart-Cussac, Antonio
A1 Hernando, Blanca
A1 Franquesa, Rosa María
A1 Caballero, Rosalia
A1 Priego-Capote, Feliciano
A1 Martín, Miguel
A1 Pollán, Marina
K1 Breast neoplasm
K1 Breast cancer subtypes
K1 Desaturation indices
K1 Fats
K1 EpiGEICAM
K1 Neoplasias de la mama
K1 Grasas
K1 Estudios de casos y controles
K1 Fosfolípidos
K1 Ácidos grasos
AB This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
PB MDPI
YR 2020
FD 2020-10-14
LK http://hdl.handle.net/10668/3895
UL http://hdl.handle.net/10668/3895
LA en
NO Lope V, Guerrero-Zotano Á, Casas A, Baena-Cañada JM, Bermejo B, Pérez-Gómez B, et al. Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype. Nutrients. 2020 Oct 14;12(10):3132
DS RISalud
RD Apr 11, 2025