%0 Journal Article
%A Lope, Virginia
%A Guerrero-Zotano, Ángel
%A Casas, Ana
%A Baena-Cañada, José Manuel
%A Bermejo, Begoña
%A Pérez-Gómez, Beatriz
%A Criado-Navarro, Inmaculada
%A Antolín, Silvia
%A Sánchez-Rovira, Pedro
%A Ramos-Vázquez, Manuel
%A Antón, Antonio
%A Castelló, Adela
%A García-Saénz, José Ángel
%A Muñoz, Montserrat
%A de Juan, Ana
%A Andrés, Raquel
%A Llombart-Cussac, Antonio
%A Hernando, Blanca
%A Franquesa, Rosa María
%A Caballero, Rosalia
%A Priego-Capote, Feliciano
%A Martín, Miguel
%A Pollán, Marina
%T Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype
%D 2020
%U http://hdl.handle.net/10668/3895
%X This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.
%K Breast neoplasm
%K Breast cancer subtypes
%K Desaturation indices
%K Fats
%K EpiGEICAM
%K Neoplasias de la mama
%K Grasas
%K Estudios de casos y controles
%K Fosfolípidos
%K Ácidos grasos
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