RT Journal Article
T1 Association of shivering threshold time with body composition and brown adipose tissue in young adults.
A1 Sardjoe Mishre, Aashley S D
A1 Martinez-Tellez, Borja
A1 Acosta, Francisco M
A1 Sanchez-Delgado, Guillermo
A1 Straat, Maaike E
A1 Webb, Andrew G
A1 Kan, Hermien E
A1 Rensen, Patrick C N
A1 Ruiz, Jonatan R
K1 Cold perception
K1 Shivering time
K1 Thermogenesis
K1 brown fat
AB Brown adipose tissue (BAT) increases metabolic heat production in response to cold exposure. Body size and composition are involved in the human cold response, yet the influence of BAT herein have not fully been explored. Here, we aimed to study the association of the cold-induced shivering threshold time with body composition, BAT, the perception of shivering and skin temperature in young adults. 110 young healthy adults (81 females; age = 21.7 ± 2.1 years, BMI = 24.2 ± 4.3 kg/m2) underwent 2 h of individualized cooling, followed by the quantification of BAT using a18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography-computed tomography (PET-CT) scan. Body mass index (BMI), lean mass, fat mass and body surface area (BSA) were also measured. Shivering threshold time was defined as the time until shivering occurred using an individualized cooling protocol. The shivering threshold time was on average 116.1 min for males and 125.8 min for females, and was positively associated to BMI (β = 3.106; R2 = 0.141; p = 0.001), lean mass (β = 2.295; R2 = 0.128; p = 0.001) and fat mass (β = 1.492; R2 = 0.121; p = 0.001) in females, but not in males (all p ≥ 0.409). The shivering threshold time was positively associated with BSA in males (p = 0.047) and females (p = 0.001), but it was not associated with BAT volume or [18F]FDG uptake nor with the perception of shivering and skin temperature perception in both sexes. The shivering threshold time is positively associated with whole-body adiposity and lean mass in females, but not in males. The shivering threshold time was positively associated with BSA, but no association was observed with BAT nor with the perception of shivering or skin temperature. Future research should consider the influence of body composition when applying cooling protocols among individuals with different phenotypical features.
PB Elsevier Ltd
SN 0306-4565
YR 2022
FD 2022-06-03
LK http://hdl.handle.net/10668/22341
UL http://hdl.handle.net/10668/22341
LA en
NO Sardjoe Mishre ASD, Martinez-Tellez B, Acosta FM, Sanchez-Delgado G, Straat ME, Webb AG, et al.  Association of shivering threshold time with body composition and brown adipose tissue in young adults. J Therm Biol. 2022 Aug;108:103277.
NO This study was funded by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393) and PTA 12264-I, Retos de la Sociedad (DEP 2016-79512-R) and European Regional Development Funds (ERDF), the Spanish Ministry of Education (FPU 13/03410), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigación 2016 - Excellence actions: Unit of Excellence on Exercise and Health (UCEES) - and Plan Propio de Investigación 2018: Programa Contratos-Puente, the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF, SOMM17/6107/UGR) - and the Fundación Carolina (C.2016-574,961). BMT, FAM and GSD are supported by individual postdoctoral grants from the Fundación Alfonso Martín Escudero.BMT is also supported by a Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea–NextGenerationEU (RR_C_2021_04).
DS RISalud
RD Apr 7, 2025