%0 Journal Article
%A Méndez-Echevarría, Ana
%A Sainz, Talía
%A de Felipe, Beatriz
%A Alcolea, Sonia
%A Olbrich, Peter
%A Goycochea-Valdivia, Walter A
%A Escosa-García, Luis
%A Cobo, Lorena
%A Calvo, Cristina
%A Neth, Olaf
%T High Rates of SARS-CoV-2 Family Transmission in Children of Healthcare Workers During the First Pandemic Wave in Madrid, Spain: Serologic Study.
%D 2021
%U http://hdl.handle.net/10668/17187
%X Data on SARS-CoV-2 transmission among children living with healthcare workers (HCWs) are scarce. A cross-sectional study was performed at a tertiary Hospital in Madrid, including children of HCW who suffered from SARS-CoV-2 infection between March and May 2020. Children underwent enzyme-linked immunosorbent serological study for detecting SARS-CoV-2 antibodies: VIRCELL IgG assay. One hundred thirteen children from 69 HCWs with confirmed SARS-CoV-2 infection were recruited: 47 children had positive IgG (41.6%). Children secondary attack rate was 43.7% (25% if both parents have had asymptomatic infection; 39.5% if one parent was symptomatic; and 47% when both parents had symptoms). Having a positive sibling was associated with a positive IgG result (odds ratio = 12.2; 95% confidence interval: 4.4-33.7, P  We observed a very high SARS-CoV-2 transmission in children of HCW during the first pandemic wave, especially when both parents were symptomatic. Having a positive sibling was associated with seroconversion, supporting the important role of family clusters in the transmission of SARS-CoV-2.
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