RT Journal Article
T1 Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study.
A1 Vissers, Linda E T
A1 Sluijs, Ivonne
A1 van der Schouw, Yvonne T
A1 Forouhi, Nita G
A1 Imamura, Fumiaki
A1 Burgess, Stephen
A1 Barricarte, Aurelio
A1 Boeing, Heiner
A1 Bonet, Catalina
A1 Chirlaque, Maria-Dolores
A1 Fagherazzi, Guy
A1 Franks, Paul W
A1 Freisling, Heinz
A1 Gunter, Marc J
A1 Quirós, J Ramón
A1 Ibsen, Daniel B
A1 Kaaks, Rudolf
A1 Key, Timothy
A1 Khaw, Kay T
A1 Kühn, Tilman
A1 Mokoroa, Olatz
A1 Nilsson, Peter M
A1 Overvad, Kim
A1 Pala, Valeria
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Sacerdote, Carlotta
A1 Spijkerman, Annemieke M W
A1 Tjonneland, Anne
A1 Tumino, Rosario
A1 Rodríguez-Barranco, Miguel
A1 Rolandsson, Olov
A1 Riboli, Elio
A1 Sharp, Stephen J
A1 Langenberg, Claudia
A1 Wareham, Nicholas J
AB To estimate the causal association between intake of dairy products and incident type 2 diabetes. The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression. Each additional LP allele was associated with a higher intake of milk (β 17.1 g/day, 95% CI 10.6-23.6) and milk beverages (β 2.8 g/day, 95% CI 1.0-4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (β -7.0 g/day, 95% CI -12.4 to -1.7 per additional LP allele), nonalcoholic beverages (β -18.0 g/day, 95% CI -34.4 to -1.6), and wine (β -4.8 g/day, 95% CI -9.1 to -0.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratioper 15 g/day 0.99, 95% CI 0.93-1.05). rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.
YR 2019
FD 2019-02-06
LK http://hdl.handle.net/10668/13529
UL http://hdl.handle.net/10668/13529
LA en
DS RISalud
RD Apr 19, 2025