RT Journal Article
T1 The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis.
A1 Alonso-Molero, Jéssica
A1 González-Donquiles, Carmen
A1 Palazuelos, Camilo
A1 Fernández-Villa, Tania
A1 Ramos, Elena
A1 Pollán, Marina
A1 Aragonés, Nuria
A1 Llorca, Javier
A1 Henar Alonso, M
A1 Tardón, Adonina
A1 Amiano, Pilar
A1 Moleon, José Juan Jiménez
A1 Pérez, Rosana Peiró
A1 Capelo, Rocío
A1 Molina, Antonio J
A1 Acebo, Inés Gómez
A1 Guevara, Marcela
A1 Perez-Gomez, Beatriz
A1 Lope, Virginia
A1 Huerta, José María
A1 Castaño-Vinyals, Gemma
A1 Kogevinas, Manolis
A1 Moreno, Victor
A1 Martín, Vicente
K1 Colorectal cancer
K1 Gene-environment
K1 Mediterranean diet
K1 SMAD7
K1 rs4939827
AB The objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer. We examined 1087 cases of colorectal cancer and 2409 population controls with available DNA samples from the MCC-Spain study, 2008-2012. Descriptive statistical analyses, and multivariate logistic mixed models were performed. The potential synergistic effect of rs4939827 and the Mediterranean diet pattern was evaluated with logistic regression in different strata of of adherence to the Mediterranean diet and the genotype. High adherence to Mediterrenean diet was statistically significantly associated with colorectal cancer risk. A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827. Although the decreased risk for the CC genotype was slightly more pronounced in subjects with high adherence to Mediterrenean diet, there was no statistically significant synergistic effect between genotype CC and adherence to the Mediterranean dietary pattern factors. The SMAD7 gene and specifically the allele C could be protective for colorectal cancer. An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC risk. Findings form this study indicate that high adherence to Mediterranean diet pattern has a protective role for CRC cancer probably involving the Tumor Growth Factor- β pathway in this cancer.
YR 2017
FD 2017-10-30
LK http://hdl.handle.net/10668/11748
UL http://hdl.handle.net/10668/11748
LA en
DS RISalud
RD Apr 11, 2025