RT Journal Article
T1 An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer
A1 Sanchez-Martin, Victoria
A1 Lopez-Pujante, Carmen
A1 Soriano-Rodriguez, Miguel
A1 Garcia-Salcedo, Jose A.
K1 DNA G-quadruplex
K1 RNA G-quadruplex
K1 i-Motif
K1 Cancer
K1 G-Cuádruplex
K1 Neoplasias
K1 Ácidos nucleicos
K1 Citosina
K1 ADN
K1 Guanina
K1 Oncogenes
K1 Telómero
AB Non-canonical, four-stranded nucleic acids secondary structures are present within regulatory regions in the human genome and transcriptome. To date, these quadruplex structures include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated with cancer, playing an important role in telomere maintenance and control of genetic expression of several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive molecular targets for cancer therapeutics with novel mechanisms of action. In this review, we provide a general overview about recent research on the implications of quadruplex structures in cancer, firstly gathering together DNA G-quadruplexes, RNA G-quadruplexes as well as DNA i-Motifs.
PB MDPI
YR 2020
FD 2020-11-24
LK http://hdl.handle.net/10668/3653
UL http://hdl.handle.net/10668/3653
LA en
NO Sanchez-Martin V, Lopez-Pujante C, Soriano-Rodriguez M, Garcia-Salcedo JA. An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer. Int J Mol Sci. 2020 Nov 24;21(23):8900
DS RISalud
RD Apr 6, 2025