RT Journal Article
T1 Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort.
A1 Gasull, Magda
A1 Pumarega, José
A1 Kiviranta, Hannu
A1 Rantakokko, Panu
A1 Raaschou-Nielsen, Ole
A1 Bergdahl, Ingvar A
A1 Sandanger, Torkjel Manning
A1 Goñi, Fernando
A1 Cirera, Lluís
A1 Donat-Vargas, Carolina
A1 Alguacil, Juan
A1 Iglesias, Mar
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Mancini, Francesca Romana
A1 Boutron-Ruault, Marie-Christine
A1 Severi, Gianluca
A1 Johnson, Theron
A1 Kühn, Tilman
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Peppa, Eleni
A1 Palli, Domenico
A1 Pala, Valeria
A1 Tumino, Rosario
A1 Naccarati, Alessio
A1 Panico, Salvatore
A1 Verschuren, Monique
A1 Vermeulen, Roel
A1 Rylander, Charlotta
A1 Nøst, Therese Haugdahl
A1 Rodríguez-Barranco, Miguel
A1 Molinuevo, Amaia
A1 Chirlaque, María-Dolores
A1 Ardanaz, Eva
A1 Sund, Malin
A1 Key, Tim
A1 Ye, Weimin
A1 Jenab, Mazda
A1 Michaud, Dominique
A1 Matullo, Giuseppe
A1 Canzian, Federico
A1 Kaaks, Rudolf
A1 Nieters, Alexandra
A1 Nöthlings, Ute
A1 Jeurnink, Suzanne
A1 Chajes, Veronique
A1 Matejcic, Marco
A1 Gunter, Marc
A1 Aune, Dagfinn
A1 Riboli, Elio
A1 Agudo, Antoni
A1 Gonzalez, Carlos Alberto
A1 Weiderpass, Elisabete
A1 Bueno-de-Mesquita, Bas
A1 Duell, Eric J
A1 Vineis, Paolo
A1 Porta, Miquel
K1 Biomarkers, methods
K1 Disease progression bias
K1 Environmental epidemiology
K1 Lipids
K1 Pancreatic cancer
K1 Persistent organic pollutants
AB The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles. Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models. There were differences among countries in subjects' characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quantified 16 of the 22 POPs in more than 90% of individuals. All 22 POPs were detected in some participants, and the smallest number of POPs detected in one person was 15 (median, 19) with few differences by country. The highest concentrations were found for p,p'-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 pg/mL, respectively). We assessed the possible occurrence of disease progression bias (DPB) in eight situations defined by lipid and POP measurements, on one hand, and by four factors: interval from blood draw to index date, tumour subsite, tumour stage, and grade of differentiation, on the other. In seven of the eight situations results supported the absence of DPB. The coexistence of differences across study centres in some design features and participant characteristics is of relevance to other multicentre studies. Relationships among subjects' characteristics and among such characteristics and design features may play important roles in the forthcoming analyses on the association between plasma concentrations of POPs and pancreatic cancer risk.
YR 2018
FD 2018-11-23
LK http://hdl.handle.net/10668/13297
UL http://hdl.handle.net/10668/13297
LA en
DS RISalud
RD Apr 8, 2025