RT Journal Article
T1 Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders.
A1 Wang, Zheng
A1 Hu, Wei
A1 Lu, Chenxi
A1 Ma, Zhiqiang
A1 Jiang, Shuai
A1 Gu, Chunhu
A1 Acuña-Castroviejo, Darío
A1 Yang, Yang
K1 atherosclerosis
K1 cardiovascular diseases
K1 inflammation
K1 interleukins
K1 myocardial ischemia
AB Inflammation is an important innate immune response to infection or tissue damage. Inflammasomes are involved in the onset and development of inflammation. The NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome is the best-characterized inflammasome. Recent evidence has indicated the importance of the NLRP3 inflammasome in the pathophysiology of cardiovascular disorders. To further understand the roles of the NLRP3 inflammasome in the cardiovascular system, we provide a comprehensive overview and discuss the remaining questions. First, a summary of NLRP3 inflammasome in the cardiovascular system is introduced. Then, the associations between NLRP3 inflammasome and cardiovascular disorders are presented. Finally, we discuss existing problems and potential directions with this issue. The information compiled here summarizes recent progress, thus potentially aiding in the understanding of the NLRP3 inflammasome in cardiovascular disorders, designing experimental and clinical research about the NLRP3 inflammasome, and promoting therapeutics for cardiovascular disorders.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/13338
UL http://hdl.handle.net/10668/13338
LA en
DS RISalud
RD Apr 9, 2025