RT Journal Article
T1 Benefits of Participation in Clinical Trials: An Umbrella Review.
A1 Bouzalmate-Hajjaj, Amira
A1 Masso Guijarro, Paloma
A1 Khan, Khalid Saeed
A1 Bueno-Cavanillas, Aurora
A1 Cano-Ibañez, Naomi
K1 health changes
K1 non-participants
K1 participation
K1 randomised controlled trials
K1 systematic reviews
K1 umbrella review
AB Participation in randomised clinical trials (RCTs) entails taking part in the discovery of effects of health care interventions. The question of whether participants' outcomes are different to those of non-participants remains controversial. This umbrella review was aimed at assessing whether there are health benefits of participation in RCTs, compared to non-participation. After prospective registration (PROSPERO CRD42021287812), we searched the Medline, Scopus, Web of Science and Cochrane Library databases from inception to June 2022 to identify relevant systematic reviews with or without meta-analyses. Data extraction and study quality assessment (AMSTAR-2) were performed by two independent reviewers. Of 914 records, six systematic reviews summarising 380 comparisons of RCT participants with non-participants met the inclusion criteria. In two reviews, the majority of comparisons were in favour of participation in RCTs. Of the total of comparisons, 69 (18.7%) were in favour of participation, reporting statistically significant better outcomes for patients treated within RCTs, 264 (71.7%) comparisons were not statistically significant, and 35 (9.5%) comparisons were in favour of non-participation. None of the reviews found a harmful effect of participation in RCTs. Our findings suggest that taking part in RCTs may be beneficial compared to non-participation.
PB MDPI AG
YR 2022
FD 2022-11-17
LK http://hdl.handle.net/10668/21124
UL http://hdl.handle.net/10668/21124
LA en
NO Bouzalmate-Hajjaj A, Massó Guijarro P, Khan KS, Bueno-Cavanillas A, Cano-Ibáñez N. Benefits of Participation in Clinical Trials: An Umbrella Review. Int J Environ Res Public Health. 2022 Nov 21;19(22):15368.
NO This research has received funding from the Ministry of Science and Innovation, Instituto de Salud Carlos III, FEDER co-funding from European Union (PI20/01532 project), and the Centro de Investigación Biomédica en Red-Epidemiología y Salud Pública (CIBERESP/CB06/02/1014).
DS RISalud
RD Apr 19, 2025