RT Journal Article
T1 Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study.
A1 Jakszyn, Paula
A1 Cayssials, Valerie
A1 Buckland, Genevieve
A1 Perez-Cornago, Aurora
A1 Weiderpass, Elisabete
A1 Boeing, Heiner
A1 Bergmann, Manuela M
A1 Vulcan, Alexandra
A1 Ohlsson, Bodil
A1 Masala, Giovanna
A1 Cross, Amanda J
A1 Riboli, Elio
A1 Ricceri, Fulvio
A1 Dahm, Christina C
A1 Nyvang, Dorthe
A1 Katzke, Verena A
A1 Kühn, Tilman
A1 Kyrø, Cecilie
A1 Tjønneland, Anne
A1 Ward, Heather A
A1 Tsilidis, Konstantinos K
A1 Skeie, Guri
A1 Sieri, Sabina
A1 Sanchez-Perez, Maria-Jose
A1 Huerta, Jose M
A1 Amiano, Pilar
A1 Lasheras, Cristina
A1 Ardanaz, Eva
A1 Mahamat-Saleh, Yahya
A1 Boutron-Ruault, Marie-Christine
A1 Carbonnel, Franck
A1 Panico, Salvatore
A1 Peppa, Eleni
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 Tumino, Rosario
A1 Vermeulen, Roel
A1 Jenab, Mazda
A1 Gunter, Marc
A1 Agudo, Antonio
K1 Europe
K1 association
K1 colorectal cancer
K1 epidemiology
K1 inflammatory potential of the diet
K1 prospective cohort
AB Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04-1.27) for CRC, 1.24 (95% CI 1.09-1.41) for colon cancer and 0.99 (95% CI 0.83-1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS was 1.62 (95% CI 1.31-2.01) for colon cancer overall and 2.11 (95% CI 1.50-2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men.
PB John Wiley & Sons, Inc.
YR 2019
FD 2019-12-12
LK http://hdl.handle.net/10668/14961
UL http://hdl.handle.net/10668/14961
LA en
NO Jakszyn P, Cayssials V, Buckland G, Perez-Cornago A, Weiderpass E, Boeing H, et al. Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. Int J Cancer. 2020 Aug 15;147(4):1027-1039.
NO This study has been funded by the Instituto de Salud Carlos III through the project PI15/00639 (cofunded by the European Regional Development Fund, ERDF, a way to build Europe). Institutional support from the CERCA Programme/Generalitat de Catalunya is acknowledged, as well as funding from the Regional Government of Asturias, German Cancer Aid, the German Cancer Research Center (DKFZ), and the Federal Ministry of Education and Research (BMBF).  The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts receive support from the Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Éducation Nationale, and the Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, and the Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro (AIRC) and the National Research Council (Italy); the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), and Statistics Netherlands (The Netherlands); ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence Programme on Food, Nutrition and Health (Norway); and the Health Research Fund (FIS).
DS RISalud
RD Jul 29, 2025