RT Journal Article
T1 Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial.
A1 Cantero, Irene
A1 Abete, Itziar
A1 Babio, Nancy
A1 Arós, Fernando
A1 Corella, Dolores
A1 Estruch, Ramón
A1 Fitó, Montse
A1 Hebert, James R
A1 Martínez-González, M Ángel
A1 Pintó, Xavier
A1 Portillo, M Puy
A1 Ruiz-Canela, Miguel
A1 Shivappa, Nitin
A1 Wärnberg, Julia
A1 Gómez-Gracia, Enrique
A1 Tur, J Antoni
A1 Salas-Salvadó, Jordi
A1 Zulet, M Angeles
A1 Martínez, J Alfredo
K1 Diet
K1 Inflammation
K1 Liver
K1 NAFLD
K1 Obesity
AB To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-α and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.
YR 2017
FD 2017-07-06
LK http://hdl.handle.net/10668/11431
UL http://hdl.handle.net/10668/11431
LA en
DS RISalud
RD Apr 11, 2025