TY - JOUR AU - Decara, Juan AU - Serrano, Antonia AU - Pavón, Francisco Javier AU - Rivera, Patricia AU - Arco, Rocio AU - Gavito, Ana AU - Vargas, Antonio AU - Navarro, Juan A AU - Tovar, Ruben AU - Lopez-Gambero, Antonio J AU - Martínez, Ana AU - Suárez, Juan AU - Rodríguez de Fonseca, Fernando AU - Baixeras, Elena PY - 2018 DO - 10.1038/s41598-018-27871-7 UR - http://hdl.handle.net/10668/12661 T2 - Scientific reports AB - Chronic NP-1 administration reduces body weight and hepatic steatosis despite induction of tolerance in adiponectin gene transcription with respect to the acute actions of this drug. This study explored the hypothesis that NP-1 could exert these... LA - en KW - Adiponectin KW - Adipose Tissue, Brown KW - Animals KW - Body Weight KW - DNA (Cytosine-5-)-Methyltransferase 1 KW - Dyslipidemias KW - Feeding Behavior KW - Gene Expression Regulation KW - Hypothalamus KW - Liver KW - Male KW - Obesity KW - Promoter Regions, Genetic KW - Rats KW - Rats, Zucker KW - Thiazoles KW - Thinness KW - Tumor Necrosis Factor-alpha KW - Weight Loss TI - The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats. TY - research article VL - 8 ER -