RT Journal Article
T1 Immune Cell Associations with Cancer Risk.
A1 Palomero, Luis
A1 Galván-Femenía, Ivan
A1 de Cid, Rafael
A1 Espín, Roderic
A1 Barnes, Daniel R
A1 Cimba, 
A1 Blommaert, Eline
A1 Gil-Gil, Miguel
A1 Falo, Catalina
A1 Stradella, Agostina
A1 Ouchi, Dan
A1 Roso-Llorach, Albert
A1 Violan, Concepció
A1 Peña-Chilet, María
A1 Dopazo, Joaquín
A1 Extremera, Ana Isabel
A1 García-Valero, Mar
A1 Herranz, Carmen
A1 Mateo, Francesca
A1 Mereu, Elisabetta
A1 Beesley, Jonathan
A1 Chenevix-Trench, Georgia
A1 Roux, Cecilia
A1 Mak, Tak
A1 Brunet, Joan
A1 Hakem, Razq
A1 Gorrini, Chiara
A1 Antoniou, Antonis C
A1 Lázaro, Conxi
A1 Pujana, Miquel Angel
K1 Cancer
K1 Cancer Systems Biology
K1 Immunology
AB Proper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we report 57 cancer risk loci associated with differences in immune and/or stromal cell contents in the corresponding tissue. Predicted target genes show expression and regulatory associations with immune features. Polygenic risk scores also reveal associations with immune and/or stromal cell contents, and breast cancer scores show consistent results in normal and tumor tissue. SH2B3 links peripheral alterations of several immune cell types to the risk of this malignancy. Pleiotropic SH2B3 variants are associated with breast cancer risk in BRCA1/2 mutation carriers. A retrospective case-cohort study indicates a positive association between blood counts of basophils, leukocytes, and monocytes and age at breast cancer diagnosis. These findings broaden our knowledge of the role of the immune system in cancer and highlight promising prevention strategies for individuals at high risk.
YR 2020
FD 2020-06-20
LK https://hdl.handle.net/10668/26258
UL https://hdl.handle.net/10668/26258
LA en
DS RISalud
RD Apr 6, 2025