RT Journal Article
T1 The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18 F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults.
A1 Martinez-Tellez, Borja
A1 Adelantado-Renau, Mireia
A1 Acosta, Francisco M
A1 Sanchez-Delgado, Guillermo
A1 Martinez-Nicolas, Antonio
A1 Boon, Mariëtte R
A1 Llamas-Elvira, Jose M
A1 Martinez-Vizcaino, Vicente
A1 Ruiz, Jonatan R
K1 Temperature
K1 Wrist
K1 Skin Temperature
K1 Hot Temperature
K1 Positron Emission Tomography Computed Tomography
K1 Hot Temperature
K1 Vasoconstriction
AB This study aimed to examine whether brown adipose tissue (BAT) or skeletal muscle activity mediates the relationship between personal level of environmental temperature (Personal-ET) and wrist skin temperature (WT). Moreover, we examined whether BAT and skeletal muscle have a mediating role between Personal-ET and WT (as a proxy of peripheral vasoconstriction/vasodilation). The levels of BAT were quantified by cold-induced 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography scan and measured the Personal-ET and WT by using iButtons (Maxim Integrated, Dallas, Texas) in 75 participants (74.6% women). The study found that BAT volume and metabolic activity played a positive and significant role (up to 25.4%) in the association between Personal-ET and WT. In addition, at the coldest temperatures, the participants with lower levels of WT (inducing higher peripheral vasoconstriction) had higher levels of BAT outcomes, whereas in warm temperatures, participants with higher levels of WT (inducing higher peripheral vasodilation) had lower levels of BAT outcomes. The study did not find any mediating role of skeletal muscle activity. BAT volume and metabolic activity play a role in the relationship between Personal-ET and WT. Moreover, the data suggest that there are two distinct phenotypes: individuals who respond better to the cold, both through nonshivering thermogenesis and peripheral vasoconstriction, and individuals who respond better to the heat.
PB Wiley-Blackwell Publishing, Inc.
YR 2019
FD 2019-02-19
LK http://hdl.handle.net/10668/13857
UL http://hdl.handle.net/10668/13857
LA en
NO Martinez-Tellez B, Adelantado-Renau M, Acosta FM, Sanchez-Delgado G, Martinez-Nicolas A, Boon MR, et al. The Mediating Role of Brown Fat and Skeletal Muscle Measured by 18 F-Fluorodeoxyglucose in the Thermoregulatory System in Young Adults. Obesity (Silver Spring). 2019 Jun;27(6):963-970.
NO : This study was supported by the Spanish Ministry of Economy and Competitiveness, Fondo de Investigación Sanitaria del Instituto de Salud Carlos III(PI13/01393), Retos de la Sociedad (DEP2016-79512-R), and Fondos Estructurales de la Unión Europea (FEDER); by the Spanish Ministry of Education (FPU 13/04365); bythe Fundación Iberoamericana de Nutrición; by the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022); by AstraZeneca HealthCare Foundation;by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES); and by theJunta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR, ProgramaContratos-Puente. MAR is supported by a predoctoral research grant from University Jaume I (PREDOC/2015/13). AMN was supported by the Ministry of Economy andCompetitiveness, the Instituto de Salud Carlos III through the Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CB16/10/00239), and grant19899/GERM/15 (cofinanced by FEDER)
DS RISalud
RD Apr 12, 2025