RT Journal Article
T1 Biosynthesis and Heterologous Expression of Cacaoidin, the First Member of the Lanthidin Family of RiPPs.
A1 Román-Hurtado, Fernando
A1 Sánchez-Hidalgo, Marina
A1 Martín, Jesús
A1 Ortiz-López, Francisco Javier
A1 Genilloud, Olga
K1 RiPP
K1 Streptomyces cacaoi
K1 cacaoidin
K1 class V lanthipeptide
K1 heterologous expression
K1 lanthidin
AB Cacaoidin is produced by the strain Streptomyces cacaoi CA-170360 and represents the first member of the new lanthidin (class V lanthipeptides) RiPP family. In this work, we describe the complete identification, cloning and heterologous expression of the cacaoidin biosynthetic gene cluster, which shows unique RiPP genes whose functions were not predicted by any bioinformatic tool. We also describe that the cacaoidin pathway is restricted to strains of the subspecies Streptomyces cacaoi subsp. cacaoi found in public genome databases, where we have also identified the presence of other putative class V lanthipeptide pathways. This is the first report on the heterologous production of a class V lanthipeptide.
SN 2079-6382
YR 2021
FD 2021-04-08
LK http://hdl.handle.net/10668/17666
UL http://hdl.handle.net/10668/17666
LA en
DS RISalud
RD Apr 11, 2025