TY - JOUR AU - Pericuesta, Eva AU - Laguna-Barraza, Ricardo AU - Ramos-Ibeas, Priscila AU - Gutierrez-Arroyo, Julia L. AU - Navarro, Juan A. AU - Vera, Katia AU - Sanjuan, Carlos AU - Baixeras, Elena AU - Rodríguez de Fonseca, Fernando AU - Gutierrez-Adan, Alfonso PY - 2020 DO - 10.3390/ijms21176049 UR - http://hdl.handle.net/10668/3863 T2 - International Journal of Molecular Sciences AB - Polycystic ovarian syndrome (PCOS) is the main cause of female infertility. It is a multifactorial disorder with varying clinical manifestations including metabolic/endocrine abnormalities, hyperandrogenism, and ovarian cysts, among other conditions.... LA - en PB - MDPI KW - Polycystic ovary syndrome KW - D-chiro-inositol KW - Oocyte KW - Embryo KW - Fertility KW - Oxidative stress KW - Glucose intolerance KW - Síndrome del ovario poliquístico KW - Oocitos KW - Estructuras embrionarias KW - Fertilidad KW - Estrés oxidativo KW - Intolerancia a la glucosa KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Aging KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Anatomy::Embryonic Structures::Embryo, Mammalian::Blastocyst KW - Medical Subject Headings::Anatomy::Cells::Endocrine Cells::Granulosa Cells::Cumulus Cells KW - Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Androstanes::Androstanols::Dihydrotestosterone KW - Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation KW - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperglycemia::Glucose Intolerance KW - Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Infertility::Infertility, Female KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Sugar Alcohols::Inositol KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Inbred Strains KW - Medical Subject Headings::Anatomy::Cells::Germ Cells::Ovum::Oocytes KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation KW - Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Adnexal Diseases::Ovarian Diseases::Ovarian Cysts::Polycystic Ovary Syndrome KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins::Proto-Oncogene Proteins c-akt KW - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones::Testosterone Congeners::Testosterone::Testosterone Propionate TI - D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome TY - research article ER -