%0 Journal Article %A Urbina, Jesus %A Sotelo, Julio A %A Springmüller, Daniel %A Montalba, Cristian %A Letelier, Karis %A Tejos, Cristian %A Irarrazaval, Pablo %A Andia, Marcelo E %A Razavi, Reza %A Valverde, Israel %A Uribe, Sergio A %T Realistic aortic phantom to study hemodynamics using MRI and cardiac catheterization in normal and aortic coarctation conditions. %D 2016 %U http://hdl.handle.net/10668/9912 %X To design and characterize a magnetic resonance imaging (MRI)-compatible aortic phantom simulating normal and aortic coarctation (AoCo) conditions and to compare its hemodynamics with healthy volunteers and AoCo patients .Materials and MethodsThe phantom is composed of an MRI-compatible pump, control unit, aortic model, compliance chamber, nonreturn, and shutoff valves. The phantom without and with AoCo (13, 11, and 9 mm) was studied using 2D and 3D phase-contrast data and with a catheterization unit to measure pressures . The phantom data were compared with the mean values of 10 healthy volunteers and two AoCo patients .ResultsHemodynamic parameters in the normal phantom and healthy volunteers were: heart rate : 68/61 bpm, cardiac output : 3.5/4.5 L/min, peak flow and peak velocity (Vpeak) in the ascending aorta (AAo): 270/357 mL/s (significantly, P < 0.05) and 97/107 cm/s (not significantly, P = 0.16), and pressure in the AAo of the normal phantom of 131/58 mmHg. Hemodynamic parameters in the 13, 11, and 9 mm coarctation phantoms and Patients 1 and 2 were: heart rate : 75/75/75/97/78 bpm, cardiac output : 3.3/3.0/2.9/4.0/5.8 L/min, peak flow in the AAo: 245/265/215/244/376 mL/s, Vpeak in the AAo: 96/95/81/196/187 cm/s, Vpeak after the AoCo: 123/187/282/247/165 cm/s, pressure in the AAo: 124/56, 127/51, 133/50, 120/51 and 87/39 mmHg, and a trans-coarctation systolic pressure gradient: 7, 10, 30, 20, and 11 mmHg.ConclusionWe propose and characterize a normal and an AoCo phantom, whose hemodynamics , including velocity, flow, and pressure data are within the range of healthy volunteers and patients with AoCo. J. Magn. Reson. Imaging 2016;44:683–697. %K 3D PC-MRI %K aortic coarctation %K aortic phantom %K catheterization %K hemodynamic parameters %~