RT Journal Article
T1 On the single and multiple associations of COVID-19 post-acute sequelae: 6-month prospective cohort study.
A1 Jimenez-Rodriguez, Beatriz Maria
A1 Gutierrez-Fernandez, Jose
A1 Ramos-Urbina, Eldis Maria
A1 Romero-Ortiz, Ana Dolores
A1 Garcia-Flores, Paula Isabel
A1 Santiago-Puertas, Maria Inmaculada
A1 Martin-Lopez, Maria Jose
A1 Lopez-Milena, Genaro
A1 Fabregas, Rene
A1 Morales-Garcia, Concepcion
K1 Post-Acute COVID-19 Syndrome
K1 X-Rays
K1 Mental Health
K1 Patient Discharge
K1 COVID-19
K1 Tomography, X-Ray Computed
K1 Bronchiectasis
K1 Biomedical Research
K1 Fatigue
K1 Endoplasmic Reticulum Stress
AB Medical research is progressing to clarify the full spectrum of sub-acute and long-term effects of the post-COVID-19 syndrome. However, most manuscripts published to date only analyze the effects of post-COVID-19 in patients discharged from hospital, which may induce significant bias. Here, we propose a pioneering study to analyze the single and multiple associations between post-COVID-19 characteristics with up to 6-months of follow-up in hospitalized and non-hospitalized COVID-19 patients. The cohort study was conducted from May to October 2020 at the University Hospital Virgen de la Nieves, the leading hospital assigned for patients with COVID-19 in Granada, Spain. A total of 372 and 217 patients-with 217 and 207 included in the first and second follow-up visits-were referred 2 and 6 months after diagnosing COVID-19, respectively. We find out that post-COVID-19 clinical and mental health impairment symptoms are correlated with patient gender. Logistic adjustments showed strong statistically robust single and multiple associations of demographic, clinical, mental health, X-ray, laboratory indices, and pulmonary function variables. The functional lung tests are good predictors of chest CT imaging abnormalities in elderly patients. Bilateral lung involvement, subpleural reticulum, ground-glass opacity, peripheral lung lesions, and bronchiectasis were the most common findings of the high-resolution computed tomography images. Non-hospitalized patients suffer more severe thromboembolic events and fatigue than those hospitalized.
PB Nature Publishing Group
YR 2022
FD 2022-02-15
LK http://hdl.handle.net/10668/19592
UL http://hdl.handle.net/10668/19592
LA en
NO Jiménez-Rodríguez BM, Gutiérrez-Fernández J, Ramos-Urbina EM, Romero-Ortiz AD, García-Flores PI, Santiago-Puertas MI, et al. On the single and multiple associations of COVID-19 post-acute sequelae: 6-month prospective cohort study. Sci Rep. 2022 Mar 1;12(1):3402.
DS RISalud
RD Apr 6, 2025