%0 Journal Article
%A Jimenez-Rodriguez, Beatriz Maria
%A Gutierrez-Fernandez, Jose
%A Ramos-Urbina, Eldis Maria
%A Romero-Ortiz, Ana Dolores
%A Garcia-Flores, Paula Isabel
%A Santiago-Puertas, Maria Inmaculada
%A Martin-Lopez, Maria Jose
%A Lopez-Milena, Genaro
%A Fabregas, Rene
%A Morales-Garcia, Concepcion
%T On the single and multiple associations of COVID-19 post-acute sequelae: 6-month prospective cohort study.
%D 2022
%U http://hdl.handle.net/10668/19592
%X Medical research is progressing to clarify the full spectrum of sub-acute and long-term effects of the post-COVID-19 syndrome. However, most manuscripts published to date only analyze the effects of post-COVID-19 in patients discharged from hospital, which may induce significant bias. Here, we propose a pioneering study to analyze the single and multiple associations between post-COVID-19 characteristics with up to 6-months of follow-up in hospitalized and non-hospitalized COVID-19 patients. The cohort study was conducted from May to October 2020 at the University Hospital Virgen de la Nieves, the leading hospital assigned for patients with COVID-19 in Granada, Spain. A total of 372 and 217 patients-with 217 and 207 included in the first and second follow-up visits-were referred 2 and 6 months after diagnosing COVID-19, respectively. We find out that post-COVID-19 clinical and mental health impairment symptoms are correlated with patient gender. Logistic adjustments showed strong statistically robust single and multiple associations of demographic, clinical, mental health, X-ray, laboratory indices, and pulmonary function variables. The functional lung tests are good predictors of chest CT imaging abnormalities in elderly patients. Bilateral lung involvement, subpleural reticulum, ground-glass opacity, peripheral lung lesions, and bronchiectasis were the most common findings of the high-resolution computed tomography images. Non-hospitalized patients suffer more severe thromboembolic events and fatigue than those hospitalized.
%K Post-Acute COVID-19 Syndrome
%K X-Rays
%K Mental Health
%K Patient Discharge
%K COVID-19
%K Tomography, X-Ray Computed
%K Bronchiectasis
%K Biomedical Research
%K Fatigue
%K Endoplasmic Reticulum Stress
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