RT Journal Article
T1 Nosocomial Outbreak of Infection With Pan-Drug-Resistant Acinetobacter baumannii in a Tertiary Care University Hospital
A1 Valencia, Raquel
A1 Arroyo, Luis A
A1 Conde, Manuel
A1 Aldana, Josefa M
A1 Torres, María-José
A1 Fernández-Cuenca, Felipe
A1 Garnacho-Montero, José
A1 Cisneros, José M
A1 Ortíz, Carlos
A1 Pachón, Jerónimo
A1 Aznar, Javier
K1 Acinetobacter baumannii
K1 Antibacterianos
K1 Instituciones Oncológicas
K1 Estudios de Casos y Controles
K1 Infección Hospitalaria
K1 Brotes de Enfermedades
K1 Hospitales Universitarios
K1 Humanos
K1 Control de Infecciones
K1 Factores de Riesgo
K1 España
AB OBJECTIVETo describe what is, to our knowledge, the first nosocomial outbreak of infection with pan-drug-resistant (including colistin-resistant) Acinetobacter baumannii, to determine the risk factors associated with these types of infections, and to determine their clinical impact.DESIGNNested case-control cohort study and a clinical-microbiological study.SETTINGA 1,521-bed tertiary care university hospital in Seville, Spain.PATIENTSCase patients were inpatients who had a pan-drug-resistant A. baumannii isolate recovered from a clinical or surveillance sample obtained at least 48 hours after admission to an intensive care unit (ICU) during the time of the epidemic outbreak. Control patients were patients who were admitted to any of the "boxes" (ie, rooms that partition off a distinct area for a patient's bed and the equipment needed to care for the patient) of an ICU for at least 48 hours during the time of the epidemic outbreak.RESULTSAll the clinical isolates had similar antibiotic susceptibility patterns (ie, they were resistant to all the antibiotics tested, including colistin), and, on the basis of repetitive extragenic palindromic-polymerase chain reaction, it was determined that all of them were of the same clone. The previous use of quinolones and glycopeptides and an ICU stay were associated with the acquisition of infection or colonization with pan-drug-resistant A. baumannii. To control this outbreak, we implemented the following multicomponent intervention program: the performance of environmental decontamination of the ICUs involved, an environmental survey, a revision of cleaning protocols, active surveillance for colonization with pan-drug-resistant A. baumannii, educational programs for the staff, and the display of posters that illustrate contact isolation measures and antimicrobial use recommendations.CONCLUSIONSWe were not able to identify the common source for these cases of infection, but the adopted measures have proven to be effective at controlling the outbreak.
PB University of Chicago Press
PB The Society for Healthcare Epidemiology of America
SN 0899-823X
YR 2009
FD 2009-03
LK http://hdl.handle.net/10668/1672
UL http://hdl.handle.net/10668/1672
LA en
NO Valencia R, Arroyo LA, Conde M, Aldana JM, Torres MJ, Fernández-Cuenca F, et al. Nosocomial outbreak of infection with pan-drug-resistant Acinetobacter baumannii in a tertiary care university hospital. Infect Control Hosp Epidemiol. 2009                         ; 30(3):257-63
NO Journal Article;
DS RISalud
RD Apr 17, 2025