RT Journal Article T1 Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update. A1 Jiménez-Sánchez, Andrés A1 Martínez-Ortega, Antonio Jesús A1 Remón-Ruiz, Pablo Jesús A1 Piñar-Gutiérrez, Ana A1 Pereira-Cunill, José Luis A1 García-Luna, Pedro Pablo K1 Mediterranean diet K1 cancer K1 diabetes mellitus K1 enteral nutrition K1 hydroxytyrosol K1 oleic acid K1 oleocanthal K1 oleuropein K1 olive oil K1 parenteral nutrition AB Extra virgin olive oil (EVOO) is a cornerstone of the Mediterranean diet (MedD). In this narrative review, we synthesize and illustrate the various characteristics and clinical applications of EVOO and its components-such as oleic acid, hydroxytyrosol, and oleuropein-in the field of clinical nutrition and dietetics. The evidence is split into diet therapy, oleic acid-based enteral nutrition formulations and oral supplementation formulations, oleic acid-based parenteral nutrition, and nutraceutical supplementation of minor components of EVOO. EVOO has diverse beneficial health properties, and current evidence supports the use of whole EVOO in diet therapy and the supplementation of its minor components to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus in clinical nutrition. Nevertheless, more intervention studies in humans are needed to chisel specific recommendations for its therapeutic use through different formulations in other specific diseases and clinical populations. YR 2022 FD 2022-03-31 LK http://hdl.handle.net/10668/21467 UL http://hdl.handle.net/10668/21467 LA en DS RISalud RD Apr 8, 2025