RT Journal Article
T1 Fishing anti(lymph)angiogenic drugs with zebrafish.
A1 García-Caballero, Melissa
A1 Quesada, Ana R
A1 Medina, Miguel A
A1 Marí-Beffa, Manuel
AB Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models. Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph)angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays.
YR 2017
FD 2017-10-31
LK http://hdl.handle.net/10668/11744
UL http://hdl.handle.net/10668/11744
LA en
DS RISalud
RD Apr 5, 2025