%0 Journal Article
%A García-Caballero, Melissa
%A Quesada, Ana R
%A Medina, Miguel A
%A Marí-Beffa, Manuel
%T Fishing anti(lymph)angiogenic drugs with zebrafish.
%D 2017
%U http://hdl.handle.net/10668/11744
%X Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models. Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph)angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays.
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